RIFM fragrance ingredient safety assessment, 2-ethyl-1-hexanol, CAS registry number 104-76-7

A. M. Api, D. Belsito, S. Bhatia, M. Bruze, P. Calow, M. L. Dagli, W. Dekant, A. D. Fryer, L. Kromidas, S. La Cava, J. F. Lalko, A. Lapczynski, D. C. Liebler, T. M. Penning, V. T. Politano, G. Ritacco, D. Salvito, T. W. Schultz, J. Shen, I. G. SipesB. Wall, D. K. Wilcox

Research output: Contribution to journalShort surveypeer-review

Abstract

The use of this material under current conditions is supported by existing information. This material was evaluated for genotoxicity, repeated dose toxicity, developmental toxicity, reproductive toxicity, local respiratory toxicity, phototoxicity, skin sensitization, as well as environmental safety. Data show that this material is not genotoxic. Data from the suitable read across analog 2-butyloctan-1-ol (CAS # 3913-02-8) show that this material does not have skin sensitization potential. The reproductive and local respiratory toxicity endpoints were completed using the TTC (Threshold of Toxicological Concern) for a Cramer Class I material (0.03 and 1.4 mg/day, respectively). The developmental and repeat dose toxicity endpoints were completed data on the target material which provided a MOE > 100. The phototoxicity/photoallergenicity endpoint was completed based on suitable UV spectra. The environmental endpoint was completed as described in the RIFM Framework.

Original languageEnglish (US)
Pages (from-to)S147-S156
JournalFood and Chemical Toxicology
Volume97
DOIs
StatePublished - Nov 1 2016

Keywords

  • Environmental Safety
  • Genotoxicity
  • Local Respiratory Toxicity
  • Phototoxicity/Photoallergenicity
  • Repeated dose, Developmental and Reproductive Toxicity
  • Skin Sensitization

ASJC Scopus subject areas

  • Food Science
  • Toxicology

Fingerprint Dive into the research topics of 'RIFM fragrance ingredient safety assessment, 2-ethyl-1-hexanol, CAS registry number 104-76-7'. Together they form a unique fingerprint.

Cite this