Rhesus rhadinovirus establishes a latent infection in B lymphocytes in vivo

Eric P. Bergquam, Nancy Avery, Stanley M. Shiigi, Michael K. Axthelm, Scott W. Wong

    Research output: Contribution to journalArticlepeer-review

    39 Scopus citations

    Abstract

    Recent DNA sequence analysis indicates that rhesus rhadinovirus (RRV) is a member of the lymphotropic gamma-2 herpesvirus family. To determine if RRV is lymphotropic, peripheral blood mononuclear cells from naturally infected monkeys were separated by immunomagnetic bead depletion and analyzed for the presence of RRV by virus isolation and nested PCR. The recovery and consistent detection of RRV in the CD20+-enriched fraction clearly demonstrates that B lymphocytes are a major site of virus persistence.

    Original languageEnglish (US)
    Pages (from-to)7874-7876
    Number of pages3
    JournalJournal of virology
    Volume73
    Issue number9
    DOIs
    StatePublished - 1999

    ASJC Scopus subject areas

    • Microbiology
    • Immunology
    • Insect Science
    • Virology

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