Rhesus rhadinovirus establishes a latent infection in B lymphocytes in vivo

Eric P. Bergquam; Nancy Avery; Stanley M. Shiigi; Michael K. Axthelm; Scott W. Wong

doi:10.1128/jvi.73.9.7874-7876.1999

Rhesus rhadinovirus establishes a latent infection in B lymphocytes in vivo

Eric P. Bergquam, Nancy Avery, Stanley M. Shiigi, Michael K. Axthelm, Scott W. Wong

Research output: Contribution to journal › Article › peer-review

40 Scopus citations

Abstract

Recent DNA sequence analysis indicates that rhesus rhadinovirus (RRV) is a member of the lymphotropic gamma-2 herpesvirus family. To determine if RRV is lymphotropic, peripheral blood mononuclear cells from naturally infected monkeys were separated by immunomagnetic bead depletion and analyzed for the presence of RRV by virus isolation and nested PCR. The recovery and consistent detection of RRV in the CD20⁺-enriched fraction clearly demonstrates that B lymphocytes are a major site of virus persistence.

Original language	English (US)
Pages (from-to)	7874-7876
Number of pages	3
Journal	Journal of virology
Volume	73
Issue number	9
DOIs	https://doi.org/10.1128/jvi.73.9.7874-7876.1999
State	Published - 1999

ASJC Scopus subject areas

Microbiology
Immunology
Insect Science
Virology

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10.1128/jvi.73.9.7874-7876.1999

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abstract = "Recent DNA sequence analysis indicates that rhesus rhadinovirus (RRV) is a member of the lymphotropic gamma-2 herpesvirus family. To determine if RRV is lymphotropic, peripheral blood mononuclear cells from naturally infected monkeys were separated by immunomagnetic bead depletion and analyzed for the presence of RRV by virus isolation and nested PCR. The recovery and consistent detection of RRV in the CD20+-enriched fraction clearly demonstrates that B lymphocytes are a major site of virus persistence.",

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AU - Bergquam, Eric P.

AU - Avery, Nancy

AU - Shiigi, Stanley M.

AU - Axthelm, Michael K.

AU - Wong, Scott W.

PY - 1999

Y1 - 1999

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AB - Recent DNA sequence analysis indicates that rhesus rhadinovirus (RRV) is a member of the lymphotropic gamma-2 herpesvirus family. To determine if RRV is lymphotropic, peripheral blood mononuclear cells from naturally infected monkeys were separated by immunomagnetic bead depletion and analyzed for the presence of RRV by virus isolation and nested PCR. The recovery and consistent detection of RRV in the CD20+-enriched fraction clearly demonstrates that B lymphocytes are a major site of virus persistence.

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JO - Journal of virology

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IS - 9

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Rhesus rhadinovirus establishes a latent infection in B lymphocytes in vivo

Abstract

ASJC Scopus subject areas

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