Rhesus rhadinovirus establishes a latent infection in B lymphocytes in vivo

Eric P. Bergquam, Nancy Avery, Stanley M. Shiigi, Michael K. Axthelm, Scott W. Wong

Research output: Contribution to journalArticle

38 Scopus citations

Abstract

Recent DNA sequence analysis indicates that rhesus rhadinovirus (RRV) is a member of the lymphotropic gamma-2 herpesvirus family. To determine if RRV is lymphotropic, peripheral blood mononuclear cells from naturally infected monkeys were separated by immunomagnetic bead depletion and analyzed for the presence of RRV by virus isolation and nested PCR. The recovery and consistent detection of RRV in the CD20+-enriched fraction clearly demonstrates that B lymphocytes are a major site of virus persistence.

Original languageEnglish (US)
Pages (from-to)7874-7876
Number of pages3
JournalJournal of virology
Volume73
Issue number9
DOIs
StatePublished - 1999

ASJC Scopus subject areas

  • Microbiology
  • Immunology
  • Insect Science
  • Virology

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