Rhesus macaque rhadinovirus-associated disease

Ryan D. Estep, Scott W. Wong

Research output: Contribution to journalReview article

11 Scopus citations

Abstract

Rhesus macaque rhadinovirus (RRV) is a gamma-2 herpesvirus that naturally infects rhesus macaque (RM) monkeys and is closely related to human herpesvirus-8 (HHV-8)/Kaposi's sarcoma-associated herpesvirus (KSHV). Infection of immunodeficient RM induces disease in infected RM that resembles KSHV-associated pathologies. Importantly, RRV possesses homologues of KSHV ORFs that are postulated to play a role in disease development. As such, RRV has emerged as a prominent in vivo model system for examining mechanisms of infection and disease of these pathogenic herpesviruses, and has provided unique insight into how these viruses cause disease.

Original languageEnglish (US)
Pages (from-to)245-250
Number of pages6
JournalCurrent Opinion in Virology
Volume3
Issue number3
DOIs
StatePublished - Jun 2013

ASJC Scopus subject areas

  • Virology

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