Rhesus macaque rhadinovirus-associated disease

Ryan Estep, Scott Wong

Research output: Contribution to journalArticle

10 Citations (Scopus)

Abstract

Rhesus macaque rhadinovirus (RRV) is a gamma-2 herpesvirus that naturally infects rhesus macaque (RM) monkeys and is closely related to human herpesvirus-8 (HHV-8)/Kaposi's sarcoma-associated herpesvirus (KSHV). Infection of immunodeficient RM induces disease in infected RM that resembles KSHV-associated pathologies. Importantly, RRV possesses homologues of KSHV ORFs that are postulated to play a role in disease development. As such, RRV has emerged as a prominent in vivo model system for examining mechanisms of infection and disease of these pathogenic herpesviruses, and has provided unique insight into how these viruses cause disease.

Original languageEnglish (US)
Pages (from-to)245-250
Number of pages6
JournalCurrent Opinion in Virology
Volume3
Issue number3
DOIs
StatePublished - Jun 2013

Fingerprint

Rhadinovirus
Macaca mulatta
Human Herpesvirus 8
Herpesviridae
Virus Diseases
Infection
Open Reading Frames
Pathology

ASJC Scopus subject areas

  • Virology

Cite this

Rhesus macaque rhadinovirus-associated disease. / Estep, Ryan; Wong, Scott.

In: Current Opinion in Virology, Vol. 3, No. 3, 06.2013, p. 245-250.

Research output: Contribution to journalArticle

@article{158cc95b5a2640f5a4914e2a21612182,
title = "Rhesus macaque rhadinovirus-associated disease",
abstract = "Rhesus macaque rhadinovirus (RRV) is a gamma-2 herpesvirus that naturally infects rhesus macaque (RM) monkeys and is closely related to human herpesvirus-8 (HHV-8)/Kaposi's sarcoma-associated herpesvirus (KSHV). Infection of immunodeficient RM induces disease in infected RM that resembles KSHV-associated pathologies. Importantly, RRV possesses homologues of KSHV ORFs that are postulated to play a role in disease development. As such, RRV has emerged as a prominent in vivo model system for examining mechanisms of infection and disease of these pathogenic herpesviruses, and has provided unique insight into how these viruses cause disease.",
author = "Ryan Estep and Scott Wong",
year = "2013",
month = "6",
doi = "10.1016/j.coviro.2013.05.016",
language = "English (US)",
volume = "3",
pages = "245--250",
journal = "Current Opinion in Virology",
issn = "1879-6257",
publisher = "Elsevier BV",
number = "3",

}

TY - JOUR

T1 - Rhesus macaque rhadinovirus-associated disease

AU - Estep, Ryan

AU - Wong, Scott

PY - 2013/6

Y1 - 2013/6

N2 - Rhesus macaque rhadinovirus (RRV) is a gamma-2 herpesvirus that naturally infects rhesus macaque (RM) monkeys and is closely related to human herpesvirus-8 (HHV-8)/Kaposi's sarcoma-associated herpesvirus (KSHV). Infection of immunodeficient RM induces disease in infected RM that resembles KSHV-associated pathologies. Importantly, RRV possesses homologues of KSHV ORFs that are postulated to play a role in disease development. As such, RRV has emerged as a prominent in vivo model system for examining mechanisms of infection and disease of these pathogenic herpesviruses, and has provided unique insight into how these viruses cause disease.

AB - Rhesus macaque rhadinovirus (RRV) is a gamma-2 herpesvirus that naturally infects rhesus macaque (RM) monkeys and is closely related to human herpesvirus-8 (HHV-8)/Kaposi's sarcoma-associated herpesvirus (KSHV). Infection of immunodeficient RM induces disease in infected RM that resembles KSHV-associated pathologies. Importantly, RRV possesses homologues of KSHV ORFs that are postulated to play a role in disease development. As such, RRV has emerged as a prominent in vivo model system for examining mechanisms of infection and disease of these pathogenic herpesviruses, and has provided unique insight into how these viruses cause disease.

UR - http://www.scopus.com/inward/record.url?scp=84880317057&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=84880317057&partnerID=8YFLogxK

U2 - 10.1016/j.coviro.2013.05.016

DO - 10.1016/j.coviro.2013.05.016

M3 - Article

C2 - 23747119

AN - SCOPUS:84880317057

VL - 3

SP - 245

EP - 250

JO - Current Opinion in Virology

JF - Current Opinion in Virology

SN - 1879-6257

IS - 3

ER -