Reward Anticipation Is Encoded Differently by Adolescent Ventral Tegmental Area Neurons

Yunbok Kim, Nicholas W. Simon, Jesse Wood, Bita Moghaddam

Research output: Contribution to journalArticle

7 Citations (Scopus)

Abstract

Background Elucidating the neurobiology of the adolescent brain is fundamental to our understanding of the etiology of psychiatric disorders such as schizophrenia and addiction, the symptoms of which often manifest during this developmental period. Dopamine neurons in the ventral tegmental area (VTA) are strongly implicated in adolescent behavioral and psychiatric vulnerabilities, but little is known about how adolescent VTA neurons encode information during motivated behavior. Methods We recorded daily from VTA neurons in adolescent and adult rats during learning and maintenance of a cued, reward-motivated instrumental task and extinction from this task. Results During performance of the same motivated behavior, identical events were encoded differently by adult and adolescent VTA neurons. Adolescent VTA neurons with dopamine-like characteristics lacked a reward anticipation signal and showed a smaller response to reward delivery compared with adults. After extinction, however, these neurons maintained a strong phasic response to cues formerly predictive of reward opportunity. Conclusions Anticipatory neuronal activity in the VTA supports preparatory attention and is implicated in error prediction signaling. Absence of this activity, combined with persistent representations of previously rewarded experiences, may provide a mechanism for rash decision making in adolescents.

Original languageEnglish (US)
Pages (from-to)878-886
Number of pages9
JournalBiological Psychiatry
Volume79
Issue number11
DOIs
StatePublished - Jun 1 2016
Externally publishedYes

Fingerprint

Ventral Tegmental Area
Reward
Neurons
Dopaminergic Neurons
Adolescent Psychiatry
Neurobiology
Exanthema
Cues
Psychiatry
Schizophrenia
Decision Making
Maintenance
Learning
Brain

Keywords

  • Adolescent
  • Dopamine
  • Extinction
  • Instrumental learning
  • Reward
  • Ventral tegmental area

ASJC Scopus subject areas

  • Biological Psychiatry

Cite this

Reward Anticipation Is Encoded Differently by Adolescent Ventral Tegmental Area Neurons. / Kim, Yunbok; Simon, Nicholas W.; Wood, Jesse; Moghaddam, Bita.

In: Biological Psychiatry, Vol. 79, No. 11, 01.06.2016, p. 878-886.

Research output: Contribution to journalArticle

Kim, Yunbok ; Simon, Nicholas W. ; Wood, Jesse ; Moghaddam, Bita. / Reward Anticipation Is Encoded Differently by Adolescent Ventral Tegmental Area Neurons. In: Biological Psychiatry. 2016 ; Vol. 79, No. 11. pp. 878-886.
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