Revisiting the central gland anatomy via MRI

Does the central gland extend below the level of verumontanum?

Barry Hansford, Yahui Peng, Yulei Jiang, Hikmat Al-Ahmadie, Scott Eggener, Ambereen Yousuf, Aytekin Oto

Research output: Contribution to journalArticle

4 Citations (Scopus)

Abstract

Purpose To determine whether the central gland of the prostate, composed of both central and transition zones, extends below the verumontanum in patients over age 43 based on prostate magnetic resonance imaging (MRI). Materials and Methods In all, 82 patients who underwent preoperative, multiparametric endorectal MRI (1.5T and 3T) at our institution were included. The central gland was defined as a combination of the central zone and transition zone. Two radiologists measured central gland extension below verumontanum using axial, coronal, and sagittal T2-weighted images and coregistration picture archiving and communication system software. Results The final cohort consisted of 63 patients with a mean age of 60.2 years (standard deviation: 7.1, range: 43-76). The central gland extended below the verumontanum in 60/63 (95%) patients. Mean central gland extension below the verumontanum was 6.5 mm (standard deviation = 3.7, range: 0, 18). Weak (r = 0.35), but significant (P = 0.005) positive correlation was found between age and the amount of central gland extension below the verumontanum. Conclusion Contrary to McNeal's classical prostatic anatomy teaching, the central gland extends below the verumontanum in 95% of men over 43, likely due to deformation of the gland by benign prostatic hyperplasia. It is important for pathologists to be aware of this observation for accurate characterization of the zonal origin of prostate cancer below the level of the verumontanum. J. Magn. Reson. Imaging 2014;39:167-171. © 2013 Wiley Periodiacls, Inc.

Original languageEnglish (US)
Pages (from-to)167-171
Number of pages5
JournalJournal of Magnetic Resonance Imaging
Volume39
Issue number1
DOIs
StatePublished - Jan 1 2014
Externally publishedYes

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Anatomy
Magnetic Resonance Imaging
Prostate
Radiology Information Systems
Prostatic Hyperplasia
Prostatic Neoplasms
Teaching
Software

Keywords

  • anatomy
  • cancer
  • central gland
  • magnetic resonance imaging
  • prostate
  • verumontanum

ASJC Scopus subject areas

  • Radiology Nuclear Medicine and imaging

Cite this

Revisiting the central gland anatomy via MRI : Does the central gland extend below the level of verumontanum? / Hansford, Barry; Peng, Yahui; Jiang, Yulei; Al-Ahmadie, Hikmat; Eggener, Scott; Yousuf, Ambereen; Oto, Aytekin.

In: Journal of Magnetic Resonance Imaging, Vol. 39, No. 1, 01.01.2014, p. 167-171.

Research output: Contribution to journalArticle

Hansford, Barry ; Peng, Yahui ; Jiang, Yulei ; Al-Ahmadie, Hikmat ; Eggener, Scott ; Yousuf, Ambereen ; Oto, Aytekin. / Revisiting the central gland anatomy via MRI : Does the central gland extend below the level of verumontanum?. In: Journal of Magnetic Resonance Imaging. 2014 ; Vol. 39, No. 1. pp. 167-171.
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abstract = "Purpose To determine whether the central gland of the prostate, composed of both central and transition zones, extends below the verumontanum in patients over age 43 based on prostate magnetic resonance imaging (MRI). Materials and Methods In all, 82 patients who underwent preoperative, multiparametric endorectal MRI (1.5T and 3T) at our institution were included. The central gland was defined as a combination of the central zone and transition zone. Two radiologists measured central gland extension below verumontanum using axial, coronal, and sagittal T2-weighted images and coregistration picture archiving and communication system software. Results The final cohort consisted of 63 patients with a mean age of 60.2 years (standard deviation: 7.1, range: 43-76). The central gland extended below the verumontanum in 60/63 (95{\%}) patients. Mean central gland extension below the verumontanum was 6.5 mm (standard deviation = 3.7, range: 0, 18). Weak (r = 0.35), but significant (P = 0.005) positive correlation was found between age and the amount of central gland extension below the verumontanum. Conclusion Contrary to McNeal's classical prostatic anatomy teaching, the central gland extends below the verumontanum in 95{\%} of men over 43, likely due to deformation of the gland by benign prostatic hyperplasia. It is important for pathologists to be aware of this observation for accurate characterization of the zonal origin of prostate cancer below the level of the verumontanum. J. Magn. Reson. Imaging 2014;39:167-171. {\circledC} 2013 Wiley Periodiacls, Inc.",
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N2 - Purpose To determine whether the central gland of the prostate, composed of both central and transition zones, extends below the verumontanum in patients over age 43 based on prostate magnetic resonance imaging (MRI). Materials and Methods In all, 82 patients who underwent preoperative, multiparametric endorectal MRI (1.5T and 3T) at our institution were included. The central gland was defined as a combination of the central zone and transition zone. Two radiologists measured central gland extension below verumontanum using axial, coronal, and sagittal T2-weighted images and coregistration picture archiving and communication system software. Results The final cohort consisted of 63 patients with a mean age of 60.2 years (standard deviation: 7.1, range: 43-76). The central gland extended below the verumontanum in 60/63 (95%) patients. Mean central gland extension below the verumontanum was 6.5 mm (standard deviation = 3.7, range: 0, 18). Weak (r = 0.35), but significant (P = 0.005) positive correlation was found between age and the amount of central gland extension below the verumontanum. Conclusion Contrary to McNeal's classical prostatic anatomy teaching, the central gland extends below the verumontanum in 95% of men over 43, likely due to deformation of the gland by benign prostatic hyperplasia. It is important for pathologists to be aware of this observation for accurate characterization of the zonal origin of prostate cancer below the level of the verumontanum. J. Magn. Reson. Imaging 2014;39:167-171. © 2013 Wiley Periodiacls, Inc.

AB - Purpose To determine whether the central gland of the prostate, composed of both central and transition zones, extends below the verumontanum in patients over age 43 based on prostate magnetic resonance imaging (MRI). Materials and Methods In all, 82 patients who underwent preoperative, multiparametric endorectal MRI (1.5T and 3T) at our institution were included. The central gland was defined as a combination of the central zone and transition zone. Two radiologists measured central gland extension below verumontanum using axial, coronal, and sagittal T2-weighted images and coregistration picture archiving and communication system software. Results The final cohort consisted of 63 patients with a mean age of 60.2 years (standard deviation: 7.1, range: 43-76). The central gland extended below the verumontanum in 60/63 (95%) patients. Mean central gland extension below the verumontanum was 6.5 mm (standard deviation = 3.7, range: 0, 18). Weak (r = 0.35), but significant (P = 0.005) positive correlation was found between age and the amount of central gland extension below the verumontanum. Conclusion Contrary to McNeal's classical prostatic anatomy teaching, the central gland extends below the verumontanum in 95% of men over 43, likely due to deformation of the gland by benign prostatic hyperplasia. It is important for pathologists to be aware of this observation for accurate characterization of the zonal origin of prostate cancer below the level of the verumontanum. J. Magn. Reson. Imaging 2014;39:167-171. © 2013 Wiley Periodiacls, Inc.

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