Revisiting post-infectious glomerulonephritis in the emerging era of C3 glomerulopathy

Mazdak Khalighi, Shihtien Wang, Kammi J. Henriksen, Margret Bock, Mahima Keswani, Shane M. Meehan, Anthony Chang

Research output: Contribution to journalArticle

8 Citations (Scopus)

Abstract

Background:: Post-infectious glomerulonephritis (PIGN) is an immune complex-mediated glomerular injury that typically resolves. Dominant C3 deposition is characteristic of PIGN, but with the emergence of C3 glomerulonephritis (C3GN) as a distinct entity, it is unclear how the pathologic similarities between PIGN and C3GN should be reconciled. Therefore, nephrologists and nephropathologists need additional guidance at the time of biopsy. Methods: We studied 23 pediatric and young adult patients diagnosed with PIGN. Patients were divided into two groups, one with co-dominance between C3 and immunoglobulins and the other meeting proposed diagnostic criteria for C3GN. Clinical and pathological features were compared. Results: No clinical and/or pathological features could distinguish between those with C3-co-dominant deposits and those with C3 dominance. Nearly all patients in both groups regained their baseline renal function without clinical intervention. Conclusions: Although the identification of abnormalities of the alternative pathway of complement is characteristic of C3GN, testing is not widely available and the turnaround time often exceeds 1 month. Our study found that PIGN with either codominant or dominant C3 deposition in a cohort of young patients has excellent short-term outcomes. Close clinical observation for persistent abnormalities, such as hypocomplementemia, prolonged hematuria or proteinuria, is recommended to single out patients that may harbor intrinsic complement abnormalities.

Original languageEnglish (US)
Pages (from-to)397-402
Number of pages6
JournalClinical Kidney Journal
Volume9
Issue number3
DOIs
StatePublished - Jan 1 2016
Externally publishedYes

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Glomerulonephritis
Alternative Complement Pathway
Hematuria
Antigen-Antibody Complex
Proteinuria
Immunoglobulins
Young Adult
Observation
Pediatrics
Kidney
Biopsy
Wounds and Injuries

Keywords

  • Alternative pathway
  • Complement

ASJC Scopus subject areas

  • Nephrology
  • Transplantation

Cite this

Khalighi, M., Wang, S., Henriksen, K. J., Bock, M., Keswani, M., Meehan, S. M., & Chang, A. (2016). Revisiting post-infectious glomerulonephritis in the emerging era of C3 glomerulopathy. Clinical Kidney Journal, 9(3), 397-402. https://doi.org/10.1093/ckj/sfw032

Revisiting post-infectious glomerulonephritis in the emerging era of C3 glomerulopathy. / Khalighi, Mazdak; Wang, Shihtien; Henriksen, Kammi J.; Bock, Margret; Keswani, Mahima; Meehan, Shane M.; Chang, Anthony.

In: Clinical Kidney Journal, Vol. 9, No. 3, 01.01.2016, p. 397-402.

Research output: Contribution to journalArticle

Khalighi, M, Wang, S, Henriksen, KJ, Bock, M, Keswani, M, Meehan, SM & Chang, A 2016, 'Revisiting post-infectious glomerulonephritis in the emerging era of C3 glomerulopathy', Clinical Kidney Journal, vol. 9, no. 3, pp. 397-402. https://doi.org/10.1093/ckj/sfw032
Khalighi, Mazdak ; Wang, Shihtien ; Henriksen, Kammi J. ; Bock, Margret ; Keswani, Mahima ; Meehan, Shane M. ; Chang, Anthony. / Revisiting post-infectious glomerulonephritis in the emerging era of C3 glomerulopathy. In: Clinical Kidney Journal. 2016 ; Vol. 9, No. 3. pp. 397-402.
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