Review of selenite cataract

Thomas (Tom) Shearer, Larry David, Ruth S. Anderson, Mitsuyoshi Azuma

Research output: Contribution to journalArticle

113 Citations (Scopus)

Abstract

Recent advances in understanding the mechanism of selenite cataract have resulted from locating the cleavage sites on proteolyzed βcrystallins from the cataract, mimicking the insolubilization of crystallins found in the cataract in an in. vitro system, studying cataract produced in lenses cultured in selenite, and permanently or temporarily reducing the rate formation of selenite cataract by use of various inhibitors. The present review discusses the selenite cataract as a useful model for understanding the role calcium-induced proteolysis in cataract formation.

Original languageEnglish (US)
Pages (from-to)357-369
Number of pages13
JournalCurrent Eye Research
Volume11
Issue number4
DOIs
StatePublished - 1992

Fingerprint

Selenious Acid
Cataract
Crystallins
Lenses
Proteolysis
Calcium

ASJC Scopus subject areas

  • Ophthalmology
  • Sensory Systems
  • Cellular and Molecular Neuroscience

Cite this

Review of selenite cataract. / Shearer, Thomas (Tom); David, Larry; Anderson, Ruth S.; Azuma, Mitsuyoshi.

In: Current Eye Research, Vol. 11, No. 4, 1992, p. 357-369.

Research output: Contribution to journalArticle

Shearer, Thomas (Tom) ; David, Larry ; Anderson, Ruth S. ; Azuma, Mitsuyoshi. / Review of selenite cataract. In: Current Eye Research. 1992 ; Vol. 11, No. 4. pp. 357-369.
@article{a6064884492b47e5a24f9faa10d49492,
title = "Review of selenite cataract",
abstract = "Recent advances in understanding the mechanism of selenite cataract have resulted from locating the cleavage sites on proteolyzed βcrystallins from the cataract, mimicking the insolubilization of crystallins found in the cataract in an in. vitro system, studying cataract produced in lenses cultured in selenite, and permanently or temporarily reducing the rate formation of selenite cataract by use of various inhibitors. The present review discusses the selenite cataract as a useful model for understanding the role calcium-induced proteolysis in cataract formation.",
author = "Shearer, {Thomas (Tom)} and Larry David and Anderson, {Ruth S.} and Mitsuyoshi Azuma",
year = "1992",
doi = "10.3109/02713689209001789",
language = "English (US)",
volume = "11",
pages = "357--369",
journal = "Current Eye Research",
issn = "0271-3683",
publisher = "Informa Healthcare",
number = "4",

}

TY - JOUR

T1 - Review of selenite cataract

AU - Shearer, Thomas (Tom)

AU - David, Larry

AU - Anderson, Ruth S.

AU - Azuma, Mitsuyoshi

PY - 1992

Y1 - 1992

N2 - Recent advances in understanding the mechanism of selenite cataract have resulted from locating the cleavage sites on proteolyzed βcrystallins from the cataract, mimicking the insolubilization of crystallins found in the cataract in an in. vitro system, studying cataract produced in lenses cultured in selenite, and permanently or temporarily reducing the rate formation of selenite cataract by use of various inhibitors. The present review discusses the selenite cataract as a useful model for understanding the role calcium-induced proteolysis in cataract formation.

AB - Recent advances in understanding the mechanism of selenite cataract have resulted from locating the cleavage sites on proteolyzed βcrystallins from the cataract, mimicking the insolubilization of crystallins found in the cataract in an in. vitro system, studying cataract produced in lenses cultured in selenite, and permanently or temporarily reducing the rate formation of selenite cataract by use of various inhibitors. The present review discusses the selenite cataract as a useful model for understanding the role calcium-induced proteolysis in cataract formation.

UR - http://www.scopus.com/inward/record.url?scp=0026579054&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=0026579054&partnerID=8YFLogxK

U2 - 10.3109/02713689209001789

DO - 10.3109/02713689209001789

M3 - Article

VL - 11

SP - 357

EP - 369

JO - Current Eye Research

JF - Current Eye Research

SN - 0271-3683

IS - 4

ER -