Review of critical issues in the pathogenesis of atopic dermatitis

Alan D. Irvine; Lawrence F. Eichenfield; Sheila F. Friedlander; Eric L. Simpson

doi:10.12788/j.sder.2016.042

Review of critical issues in the pathogenesis of atopic dermatitis

Alan D. Irvine, Lawrence F. Eichenfield, Sheila F. Friedlander, Eric L. Simpson

Dermatology

Research output: Contribution to journal › Article › peer-review

11 Scopus citations

Abstract

About a decade age, loss-of-function mutations in the filaggrin molecule were first implicated in the pathogenesis of ichthyosis vulgaris and, subsequently, of atopic dermatitis and other atopic diseases. Since then, intensive study of the role of filaggrin null mutations have led to other milestones in understanding the pathologic pathways in these diseases, including the initiation, maintenance, and promotion of the disease processes. The result has been new and emerging clinical and pharmacologic strategies for early identification of and intervention in atopic diseases.

Original language	English (US)
Pages (from-to)	89S-91S
Journal	Seminars in cutaneous medicine and surgery
Volume	35
DOIs	https://doi.org/10.12788/j.sder.2016.042
State	Published - Jun 1 2016

Keywords

Atopic dermatitis
Eczema
Filaggrin
Filaggrin null mutation
ILC2s
Interleukin-13
Interleukin-25
Nuocytes
Toll-like receptors
Type 2 innate lymphoid cells

ASJC Scopus subject areas

Surgery
Dermatology

Access to Document

10.12788/j.sder.2016.042

Cite this

@article{d09f1fa9306b40378e7452cf7fd68f40,

title = "Review of critical issues in the pathogenesis of atopic dermatitis",

abstract = "About a decade age, loss-of-function mutations in the filaggrin molecule were first implicated in the pathogenesis of ichthyosis vulgaris and, subsequently, of atopic dermatitis and other atopic diseases. Since then, intensive study of the role of filaggrin null mutations have led to other milestones in understanding the pathologic pathways in these diseases, including the initiation, maintenance, and promotion of the disease processes. The result has been new and emerging clinical and pharmacologic strategies for early identification of and intervention in atopic diseases.",

keywords = "Atopic dermatitis, Eczema, Filaggrin, Filaggrin null mutation, ILC2s, Interleukin-13, Interleukin-25, Nuocytes, Toll-like receptors, Type 2 innate lymphoid cells",

author = "Irvine, {Alan D.} and Eichenfield, {Lawrence F.} and Friedlander, {Sheila F.} and Simpson, {Eric L.}",

note = "Publisher Copyright: {\textcopyright} 2016 published by Frontline Medical Communications.",

year = "2016",

month = jun,

day = "1",

doi = "10.12788/j.sder.2016.042",

language = "English (US)",

volume = "35",

pages = "89S--91S",

journal = "Seminars in cutaneous medicine and surgery",

issn = "1085-5629",

publisher = "W.B. Saunders Ltd",

}

TY - JOUR

T1 - Review of critical issues in the pathogenesis of atopic dermatitis

AU - Irvine, Alan D.

AU - Eichenfield, Lawrence F.

AU - Friedlander, Sheila F.

AU - Simpson, Eric L.

PY - 2016/6/1

Y1 - 2016/6/1

N2 - About a decade age, loss-of-function mutations in the filaggrin molecule were first implicated in the pathogenesis of ichthyosis vulgaris and, subsequently, of atopic dermatitis and other atopic diseases. Since then, intensive study of the role of filaggrin null mutations have led to other milestones in understanding the pathologic pathways in these diseases, including the initiation, maintenance, and promotion of the disease processes. The result has been new and emerging clinical and pharmacologic strategies for early identification of and intervention in atopic diseases.

AB - About a decade age, loss-of-function mutations in the filaggrin molecule were first implicated in the pathogenesis of ichthyosis vulgaris and, subsequently, of atopic dermatitis and other atopic diseases. Since then, intensive study of the role of filaggrin null mutations have led to other milestones in understanding the pathologic pathways in these diseases, including the initiation, maintenance, and promotion of the disease processes. The result has been new and emerging clinical and pharmacologic strategies for early identification of and intervention in atopic diseases.

KW - Atopic dermatitis

KW - Eczema

KW - Filaggrin

KW - Filaggrin null mutation

KW - ILC2s

KW - Interleukin-13

KW - Interleukin-25

KW - Nuocytes

KW - Toll-like receptors

KW - Type 2 innate lymphoid cells

UR - http://www.scopus.com/inward/record.url?scp=85020319216&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=85020319216&partnerID=8YFLogxK

U2 - 10.12788/j.sder.2016.042

DO - 10.12788/j.sder.2016.042

M3 - Article

C2 - 27525507

AN - SCOPUS:85020319216

SN - 1085-5629

VL - 35

SP - 89S-91S

JO - Seminars in cutaneous medicine and surgery

JF - Seminars in cutaneous medicine and surgery

ER -

Review of critical issues in the pathogenesis of atopic dermatitis

Abstract

Keywords

ASJC Scopus subject areas

Access to Document

Other files and links

Fingerprint

Cite this