Review: Insulin-like growth factors: The ovarian connection

Eli Y. Adashi, Carol E. Resnick, Arye Hurwitz, Elisabetta Ricciarelli, Eleuterio R. Hernandez, Charles T. Roberts, Derek Leroith, Ron Rosenfeld

Research output: Contribution to journalArticle

86 Scopus citations

Abstract

A large body of information now supports the existence of a complete intraovarian insulin-like growth factor (IGF) system replete with ligands, receptors, and binding proteins. Although much remains to be learned, the emerging consensus would suggest that the intraovarian IGF system is concerned largely with the amplification of gonadotrophin hormonal action for the facilitation of follicular growth and development. Future studies are likely to address the central issue of indispensability and the documentation of a meaningful in vivo role for this and related putative intraovarian regulators.

Original languageEnglish (US)
Pages (from-to)1213-1219
Number of pages7
JournalHuman Reproduction
Volume6
Issue number9
DOIs
StatePublished - Oct 1991

Keywords

  • CAMP
  • IGFBP
  • Insulin-like growth factor (IGF)
  • Receptor
  • Synergism

ASJC Scopus subject areas

  • Reproductive Medicine
  • Obstetrics and Gynecology

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  • Cite this

    Adashi, E. Y., Resnick, C. E., Hurwitz, A., Ricciarelli, E., Hernandez, E. R., Roberts, C. T., Leroith, D., & Rosenfeld, R. (1991). Review: Insulin-like growth factors: The ovarian connection. Human Reproduction, 6(9), 1213-1219. https://doi.org/10.1093/oxfordjournals.humrep.a137514