TY - JOUR
T1 - Review
T2 - Assessment of myocardial perfusion with contrast two-dimensional echocardiography
AU - Kaul, S.
N1 - Funding Information:
Supported, in part, by grants-in-aid from the Virginia Affiliate of the American Heart Association, Glen Allen, Virginia, and the National Center of the American Heart Association, Dallas, Texas, and, in part, by a Clinical lrwestigatur Award (K08-HL01833) and a FIRST Award (R29-HL38345) from the National Institutes of Health, Bethesda, Maryland.
PY - 1990
Y1 - 1990
N2 - Myocardial contrast echocardiography (MCE) is a new technique capable of assessing regional myocardial perfusion in vivo in real time. At present, this technique involves the intraaortic or intracoronary injection of microbubbles of air. As these microbubbles traverse the myocardium, they produce opacification of the myocardium in concomitantly performed echocardiographic images. In animal models, MCE has been demonstrated to assess accurately the in vivo risk area (region of the myocardium at risk for necrosis after acute coronary occlusion). It has also been shown to provide quantitative information on regional myocardial blood flow (both antegrade and collateral). This technique has beem demonstrated to be safe in humans. In clinical studies it has been shown to be a useful adjunct to cardiac catheterization, particularly in the assessment of coronary blood flow reserve and collateral blood flow. MCE is also used in the operating room to assess regional myocardial perfusion before and after bypass graft operations. The microbubbles used for MCE were shown to opacify the left ventricular cavity after their injection into a peripheral vein. If myocardial opacification after venous injection can be achieved, MCE will have the potential for the simultaneous myocardial perfusion and function in humans.
AB - Myocardial contrast echocardiography (MCE) is a new technique capable of assessing regional myocardial perfusion in vivo in real time. At present, this technique involves the intraaortic or intracoronary injection of microbubbles of air. As these microbubbles traverse the myocardium, they produce opacification of the myocardium in concomitantly performed echocardiographic images. In animal models, MCE has been demonstrated to assess accurately the in vivo risk area (region of the myocardium at risk for necrosis after acute coronary occlusion). It has also been shown to provide quantitative information on regional myocardial blood flow (both antegrade and collateral). This technique has beem demonstrated to be safe in humans. In clinical studies it has been shown to be a useful adjunct to cardiac catheterization, particularly in the assessment of coronary blood flow reserve and collateral blood flow. MCE is also used in the operating room to assess regional myocardial perfusion before and after bypass graft operations. The microbubbles used for MCE were shown to opacify the left ventricular cavity after their injection into a peripheral vein. If myocardial opacification after venous injection can be achieved, MCE will have the potential for the simultaneous myocardial perfusion and function in humans.
KW - intraaortic
KW - intracoronary
KW - myocardial contrast echocardiography
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U2 - 10.1097/00000441-199002000-00007
DO - 10.1097/00000441-199002000-00007
M3 - Review article
C2 - 2405663
AN - SCOPUS:0025377224
SN - 0002-9629
VL - 299
SP - 113
EP - 130
JO - American Journal of the Medical Sciences
JF - American Journal of the Medical Sciences
IS - 2
ER -