Abstract
Background Alcoholic hepatitis is a severe, cholestatic liver disease occurring in patients with alcohol abuse. Mortality is substantial; however, therapies may improve clinical outcomes. Aim To provide an updated review of the epidemiology, diagnosis, staging and treatment of alcoholic hepatitis. Methods A MEDLINE literature search was performed to identify pertinent articles. Relevant clinical abstracts were also reviewed. Results Severe alcoholic hepatitis occurs in a small fraction of patients who abuse alcohol. The 28-day mortality ranges from 30% to 50% in most series. Diagnosis is generally based on clinical features, with a limited role for liver biopsy. Beneficial treatment options include alcohol abstinence and nutritional therapy. Despite variable results in clinical trials, corticosteroids and pentoxifylline appear to provide moderate survival benefit. Anti-tumour necrosis factor agents and antioxidants have not proven beneficial, and should be limited to clinical trials. Liver transplant is not a frequent option given the active or recent alcohol use. Conclusions Severe alcoholic hepatitis is a clinically-diagnosed condition associated with significant mortality. Alcohol abstinence and nutritional therapy have been associated with improved clinical parameters and should be considered in all patients. Corticosteroid therapy and pentoxifylline therapy appear to show moderate survival benefit and should be considered as first-line therapeutic agents.
| Original language | English (US) |
|---|---|
| Pages (from-to) | 3-13 |
| Number of pages | 11 |
| Journal | Alimentary Pharmacology and Therapeutics |
| Volume | 30 |
| Issue number | 1 |
| DOIs | |
| State | Published - Jul 2009 |
| Externally published | Yes |
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ASJC Scopus subject areas
- Pharmacology (medical)
Cite this
Review article : The diagnosis and management of alcoholic hepatitis. / Cohen, S. M.; Ahn, Joseph.
In: Alimentary Pharmacology and Therapeutics, Vol. 30, No. 1, 07.2009, p. 3-13.Research output: Contribution to journal › Article
}
TY - JOUR
T1 - Review article
T2 - The diagnosis and management of alcoholic hepatitis
AU - Cohen, S. M.
AU - Ahn, Joseph
PY - 2009/7
Y1 - 2009/7
N2 - Background Alcoholic hepatitis is a severe, cholestatic liver disease occurring in patients with alcohol abuse. Mortality is substantial; however, therapies may improve clinical outcomes. Aim To provide an updated review of the epidemiology, diagnosis, staging and treatment of alcoholic hepatitis. Methods A MEDLINE literature search was performed to identify pertinent articles. Relevant clinical abstracts were also reviewed. Results Severe alcoholic hepatitis occurs in a small fraction of patients who abuse alcohol. The 28-day mortality ranges from 30% to 50% in most series. Diagnosis is generally based on clinical features, with a limited role for liver biopsy. Beneficial treatment options include alcohol abstinence and nutritional therapy. Despite variable results in clinical trials, corticosteroids and pentoxifylline appear to provide moderate survival benefit. Anti-tumour necrosis factor agents and antioxidants have not proven beneficial, and should be limited to clinical trials. Liver transplant is not a frequent option given the active or recent alcohol use. Conclusions Severe alcoholic hepatitis is a clinically-diagnosed condition associated with significant mortality. Alcohol abstinence and nutritional therapy have been associated with improved clinical parameters and should be considered in all patients. Corticosteroid therapy and pentoxifylline therapy appear to show moderate survival benefit and should be considered as first-line therapeutic agents.
AB - Background Alcoholic hepatitis is a severe, cholestatic liver disease occurring in patients with alcohol abuse. Mortality is substantial; however, therapies may improve clinical outcomes. Aim To provide an updated review of the epidemiology, diagnosis, staging and treatment of alcoholic hepatitis. Methods A MEDLINE literature search was performed to identify pertinent articles. Relevant clinical abstracts were also reviewed. Results Severe alcoholic hepatitis occurs in a small fraction of patients who abuse alcohol. The 28-day mortality ranges from 30% to 50% in most series. Diagnosis is generally based on clinical features, with a limited role for liver biopsy. Beneficial treatment options include alcohol abstinence and nutritional therapy. Despite variable results in clinical trials, corticosteroids and pentoxifylline appear to provide moderate survival benefit. Anti-tumour necrosis factor agents and antioxidants have not proven beneficial, and should be limited to clinical trials. Liver transplant is not a frequent option given the active or recent alcohol use. Conclusions Severe alcoholic hepatitis is a clinically-diagnosed condition associated with significant mortality. Alcohol abstinence and nutritional therapy have been associated with improved clinical parameters and should be considered in all patients. Corticosteroid therapy and pentoxifylline therapy appear to show moderate survival benefit and should be considered as first-line therapeutic agents.
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U2 - 10.1111/j.1365-2036.2009.04002.x
DO - 10.1111/j.1365-2036.2009.04002.x
M3 - Article
C2 - 19416132
AN - SCOPUS:67449088475
VL - 30
SP - 3
EP - 13
JO - Alimentary Pharmacology and Therapeutics
JF - Alimentary Pharmacology and Therapeutics
SN - 0269-2813
IS - 1
ER -