Reversible gastric restriction implant: Safety and efficacy in a canine model

Xiaomei Guo, Hai Zheng, Samer Mattar, Xiao Lu, George Sandusky, Jose A. Navia, Ghassan Kassab

Research output: Contribution to journalArticle

3 Scopus citations

Abstract

Background: Gastric restrictive procedures are considered effective weight loss treatment for severe obesity. The aim of the study was to evaluate the efficacy and safety of a reversible implant that renders a partial restriction of stomach in a canine model. Methods: The device was comprised of two longitudinal parallel non-compressive plates with two C-rings to create a small gastric pouch that opposed gastric distension. Three groups of non-obese mongrel dogs were included: group I (n∈=∈6) underwent surgical implant for 6 weeks, group II (n∈=∈6) underwent surgical implant for 6 weeks, followed by surgical removal of the implant and additional monitoring for 5 weeks, and group III (n∈=∈5) served as sham-operated controls for groups I and II. Food intake and body weight were monitored, and the stomachs were examined histologically postmortem. Results: The average food intake was significantly decreased by 38.2% in group I as compared to group III throughout the 6 weeks of surgical implant (P∈

Original languageEnglish (US)
Pages (from-to)1444-1450
Number of pages7
JournalObesity Surgery
Volume21
Issue number9
DOIs
Publication statusPublished - Sep 2011
Externally publishedYes

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Keywords

  • Body weight
  • Food intake
  • Implant
  • Obesity
  • Restrictive procedure

ASJC Scopus subject areas

  • Surgery
  • Endocrinology, Diabetes and Metabolism
  • Nutrition and Dietetics

Cite this

Guo, X., Zheng, H., Mattar, S., Lu, X., Sandusky, G., Navia, J. A., & Kassab, G. (2011). Reversible gastric restriction implant: Safety and efficacy in a canine model. Obesity Surgery, 21(9), 1444-1450. https://doi.org/10.1007/s11695-010-0299-4