Reverse endoventricular artificial obturator in tricuspid valve position. Experimental feasibility research study

J. Sochman, J. H. Peregrin, D. Pavcnik, B. T. Uchida, H. A. Timmermans, D. Sedmera, O. Benada, O. Kofronova, F. S. Keller, J. Rosch

Research output: Contribution to journalArticle

Abstract

The concept of vena contracta space reduction in tricuspid valve position was tested in an an imal model. Feasibility of specific artificial obturator body (REMOT) fixed to the right ventricular apex and interacting with tricuspid valve leaflets was evaluated in three different animal studies. Catheter-based technique was used in three series of experiment in 7 sheep. First acute study was designed for evaluation if the screwing mode of guide wire anchoring to the right ventricular apex is feasible for the whole REMOT body fixing. Longer study was aimed to evaluate stability of the REMOT body in desired position when fixing the screwing wire on its both ends (to the right ventricular apex and to the skin in the neck area). X-ray methods and various morphological methods were used. The third acute study was intended to the REMOT body deployment without any fixing wire. In all of 7 sheep the REMOT was successfully inserted into the right heart cavities and then fixed to the right ventricular apex area. When the REMOT was left in situ more than 6 months it was stable, induced adhesion to the tricuspid valve leaflet and was associated with a specific cell invasion. Releasing of the REMOT from the guiding tools was also successfully verified. Deployment of the obturator body in the aim to reduce the tricuspid valve orifice is feasible and well tolerated in the short and longer term animal model. Specific cell colonization including neovascularization of the obturator body was observed.

Original languageEnglish (US)
Pages (from-to)157-165
Number of pages9
JournalPhysiological Research
Volume63
Issue number2
StatePublished - 2014

Keywords

  • Catheterization
  • Myxoma-like principle
  • Tricuspid annular plane systolic excursion (TAPSE)
  • Tricuspid valve regurgitation

ASJC Scopus subject areas

  • Physiology

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    Sochman, J., Peregrin, J. H., Pavcnik, D., Uchida, B. T., Timmermans, H. A., Sedmera, D., Benada, O., Kofronova, O., Keller, F. S., & Rosch, J. (2014). Reverse endoventricular artificial obturator in tricuspid valve position. Experimental feasibility research study. Physiological Research, 63(2), 157-165.