Reversal of short photoperiod-induced sterility in male hamsters by ectopic pituitary homografts

A. Bartke, M (Susan) Smith, S. Dalterio

Research output: Contribution to journalArticle

15 Citations (Scopus)

Abstract

In the hamster testicular atrophy can be reversed by ectopic pituitary grafts but effects of this treatment on fertility have not been examined. Adult male hamsters were transferred from a long (14 h of light: 10 h of darkness) to a short photoperiod (5 h of light : 19 h of darkness) to induce atrophy of the testes. Two months later, the animals were given transplants of one or two pituitaries from adult females under the kidney capsule, were sham-operated, or left untreated. After an additional 2 months, all of 7 animals given one graft and 2 of 5 animals given two grafts were fertile while none of 10 control males sired litters. At autopsy, the concentration of testosterone in the plasma and the weights of the testes and the seminal vesicles were significantly higher in grafted than in control animals. Plasma FSH levels were increased only in animals given two transplants, while plasma LH levels were not affected by either of the treatments. Restoration of fertility by pituitary transplants was most likely due to increase in peripheral PRL concentration and in testicular LH receptor levels.

Original languageEnglish (US)
Pages (from-to)257-262
Number of pages6
JournalInternational Journal of Andrology
Volume2
Issue number3
StatePublished - 1979
Externally publishedYes

Fingerprint

Male Infertility
Photoperiod
Cricetinae
Allografts
Transplants
Darkness
Atrophy
Fertility
Testis
LH Receptors
Light
Seminal Vesicles
Capsules
Testosterone
Autopsy
Kidney
Weights and Measures

ASJC Scopus subject areas

  • Endocrinology

Cite this

Reversal of short photoperiod-induced sterility in male hamsters by ectopic pituitary homografts. / Bartke, A.; Smith, M (Susan); Dalterio, S.

In: International Journal of Andrology, Vol. 2, No. 3, 1979, p. 257-262.

Research output: Contribution to journalArticle

Bartke, A. ; Smith, M (Susan) ; Dalterio, S. / Reversal of short photoperiod-induced sterility in male hamsters by ectopic pituitary homografts. In: International Journal of Andrology. 1979 ; Vol. 2, No. 3. pp. 257-262.
@article{3894d71d94174ad2b55e7d1b90a8d883,
title = "Reversal of short photoperiod-induced sterility in male hamsters by ectopic pituitary homografts",
abstract = "In the hamster testicular atrophy can be reversed by ectopic pituitary grafts but effects of this treatment on fertility have not been examined. Adult male hamsters were transferred from a long (14 h of light: 10 h of darkness) to a short photoperiod (5 h of light : 19 h of darkness) to induce atrophy of the testes. Two months later, the animals were given transplants of one or two pituitaries from adult females under the kidney capsule, were sham-operated, or left untreated. After an additional 2 months, all of 7 animals given one graft and 2 of 5 animals given two grafts were fertile while none of 10 control males sired litters. At autopsy, the concentration of testosterone in the plasma and the weights of the testes and the seminal vesicles were significantly higher in grafted than in control animals. Plasma FSH levels were increased only in animals given two transplants, while plasma LH levels were not affected by either of the treatments. Restoration of fertility by pituitary transplants was most likely due to increase in peripheral PRL concentration and in testicular LH receptor levels.",
author = "A. Bartke and Smith, {M (Susan)} and S. Dalterio",
year = "1979",
language = "English (US)",
volume = "2",
pages = "257--262",
journal = "International Journal of Andrology",
issn = "0105-6263",
publisher = "Wiley-Blackwell",
number = "3",

}

TY - JOUR

T1 - Reversal of short photoperiod-induced sterility in male hamsters by ectopic pituitary homografts

AU - Bartke, A.

AU - Smith, M (Susan)

AU - Dalterio, S.

PY - 1979

Y1 - 1979

N2 - In the hamster testicular atrophy can be reversed by ectopic pituitary grafts but effects of this treatment on fertility have not been examined. Adult male hamsters were transferred from a long (14 h of light: 10 h of darkness) to a short photoperiod (5 h of light : 19 h of darkness) to induce atrophy of the testes. Two months later, the animals were given transplants of one or two pituitaries from adult females under the kidney capsule, were sham-operated, or left untreated. After an additional 2 months, all of 7 animals given one graft and 2 of 5 animals given two grafts were fertile while none of 10 control males sired litters. At autopsy, the concentration of testosterone in the plasma and the weights of the testes and the seminal vesicles were significantly higher in grafted than in control animals. Plasma FSH levels were increased only in animals given two transplants, while plasma LH levels were not affected by either of the treatments. Restoration of fertility by pituitary transplants was most likely due to increase in peripheral PRL concentration and in testicular LH receptor levels.

AB - In the hamster testicular atrophy can be reversed by ectopic pituitary grafts but effects of this treatment on fertility have not been examined. Adult male hamsters were transferred from a long (14 h of light: 10 h of darkness) to a short photoperiod (5 h of light : 19 h of darkness) to induce atrophy of the testes. Two months later, the animals were given transplants of one or two pituitaries from adult females under the kidney capsule, were sham-operated, or left untreated. After an additional 2 months, all of 7 animals given one graft and 2 of 5 animals given two grafts were fertile while none of 10 control males sired litters. At autopsy, the concentration of testosterone in the plasma and the weights of the testes and the seminal vesicles were significantly higher in grafted than in control animals. Plasma FSH levels were increased only in animals given two transplants, while plasma LH levels were not affected by either of the treatments. Restoration of fertility by pituitary transplants was most likely due to increase in peripheral PRL concentration and in testicular LH receptor levels.

UR - http://www.scopus.com/inward/record.url?scp=0018647894&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=0018647894&partnerID=8YFLogxK

M3 - Article

AN - SCOPUS:0018647894

VL - 2

SP - 257

EP - 262

JO - International Journal of Andrology

JF - International Journal of Andrology

SN - 0105-6263

IS - 3

ER -