Return of Human Corneal Sensitivity After Penetrating Keratoplasty

William Mathers, James V. Jester, Michael A. Lemp

Research output: Contribution to journalArticle

50 Citations (Scopus)

Abstract

To evaluate the reinnervation of corneal grafts, we studied 91 eyes of 79 patients for the return of sensitivity one month to ten years following penetrating keratoplasty for various corneal disorders including keratoconus, Fuchs' dystrophy, herpes simplex keratitis, aphakic and pseudophakic bullous keratopathy, glaucoma, trauma, and interstitial keratitis. Using the Cochet-Bonnet esthesiometer, a sensation was recorded in the center of the graft no earlier than 18 months. We found a progressive return of sensitivity from the periphery toward the center of the graft. Regression analysis indicated a rate of return of sensitivity that averaged 0.029 mm/mo for each diagnostic category except herpes simplex keratitis. The slope of the return of sensitivity in the group with herpes simplex keratitis was essentially flat, showing no central progression. None of the eight patients with herpes simplex keratitis had a sensation recorded further than 0.5 mm from the wound margin.

Original languageEnglish (US)
Pages (from-to)210-211
Number of pages2
JournalArchives of Ophthalmology
Volume106
Issue number2
DOIs
StatePublished - 1988
Externally publishedYes

Fingerprint

Herpetic Keratitis
Penetrating Keratoplasty
Transplants
Keratoconus
Keratitis
Wounds and Injuries
Glaucoma
Regression Analysis

ASJC Scopus subject areas

  • Ophthalmology

Cite this

Return of Human Corneal Sensitivity After Penetrating Keratoplasty. / Mathers, William; Jester, James V.; Lemp, Michael A.

In: Archives of Ophthalmology, Vol. 106, No. 2, 1988, p. 210-211.

Research output: Contribution to journalArticle

Mathers, William ; Jester, James V. ; Lemp, Michael A. / Return of Human Corneal Sensitivity After Penetrating Keratoplasty. In: Archives of Ophthalmology. 1988 ; Vol. 106, No. 2. pp. 210-211.
@article{c77019a906794d04a5ca66d72cf915b9,
title = "Return of Human Corneal Sensitivity After Penetrating Keratoplasty",
abstract = "To evaluate the reinnervation of corneal grafts, we studied 91 eyes of 79 patients for the return of sensitivity one month to ten years following penetrating keratoplasty for various corneal disorders including keratoconus, Fuchs' dystrophy, herpes simplex keratitis, aphakic and pseudophakic bullous keratopathy, glaucoma, trauma, and interstitial keratitis. Using the Cochet-Bonnet esthesiometer, a sensation was recorded in the center of the graft no earlier than 18 months. We found a progressive return of sensitivity from the periphery toward the center of the graft. Regression analysis indicated a rate of return of sensitivity that averaged 0.029 mm/mo for each diagnostic category except herpes simplex keratitis. The slope of the return of sensitivity in the group with herpes simplex keratitis was essentially flat, showing no central progression. None of the eight patients with herpes simplex keratitis had a sensation recorded further than 0.5 mm from the wound margin.",
author = "William Mathers and Jester, {James V.} and Lemp, {Michael A.}",
year = "1988",
doi = "10.1001/archopht.1988.01060130220030",
language = "English (US)",
volume = "106",
pages = "210--211",
journal = "JAMA Ophthalmology",
issn = "2168-6165",
publisher = "American Medical Association",
number = "2",

}

TY - JOUR

T1 - Return of Human Corneal Sensitivity After Penetrating Keratoplasty

AU - Mathers, William

AU - Jester, James V.

AU - Lemp, Michael A.

PY - 1988

Y1 - 1988

N2 - To evaluate the reinnervation of corneal grafts, we studied 91 eyes of 79 patients for the return of sensitivity one month to ten years following penetrating keratoplasty for various corneal disorders including keratoconus, Fuchs' dystrophy, herpes simplex keratitis, aphakic and pseudophakic bullous keratopathy, glaucoma, trauma, and interstitial keratitis. Using the Cochet-Bonnet esthesiometer, a sensation was recorded in the center of the graft no earlier than 18 months. We found a progressive return of sensitivity from the periphery toward the center of the graft. Regression analysis indicated a rate of return of sensitivity that averaged 0.029 mm/mo for each diagnostic category except herpes simplex keratitis. The slope of the return of sensitivity in the group with herpes simplex keratitis was essentially flat, showing no central progression. None of the eight patients with herpes simplex keratitis had a sensation recorded further than 0.5 mm from the wound margin.

AB - To evaluate the reinnervation of corneal grafts, we studied 91 eyes of 79 patients for the return of sensitivity one month to ten years following penetrating keratoplasty for various corneal disorders including keratoconus, Fuchs' dystrophy, herpes simplex keratitis, aphakic and pseudophakic bullous keratopathy, glaucoma, trauma, and interstitial keratitis. Using the Cochet-Bonnet esthesiometer, a sensation was recorded in the center of the graft no earlier than 18 months. We found a progressive return of sensitivity from the periphery toward the center of the graft. Regression analysis indicated a rate of return of sensitivity that averaged 0.029 mm/mo for each diagnostic category except herpes simplex keratitis. The slope of the return of sensitivity in the group with herpes simplex keratitis was essentially flat, showing no central progression. None of the eight patients with herpes simplex keratitis had a sensation recorded further than 0.5 mm from the wound margin.

UR - http://www.scopus.com/inward/record.url?scp=0023852133&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=0023852133&partnerID=8YFLogxK

U2 - 10.1001/archopht.1988.01060130220030

DO - 10.1001/archopht.1988.01060130220030

M3 - Article

VL - 106

SP - 210

EP - 211

JO - JAMA Ophthalmology

JF - JAMA Ophthalmology

SN - 2168-6165

IS - 2

ER -