Retinoblastoma and Chromosome Abnormality: Partial Deletion of the Long Arm of Chromosome 13

Rufus O. Howard, W. Roy Breg, Daniel Albert, Robert L. Lesser

Research output: Contribution to journalArticle

34 Citations (Scopus)

Abstract

A 7-year-old girl with retarded physical and mental development was found, on chromosome determination, to have deletion of a segment of the long arm of chromosome 13 (13 q—). A precise chromosome identification was made on peripheral leukocytes by using a quinacrine banding technique. Because of previous reports of an association of the 13 q—chromosomal abnormality with retinoblastoma, an ophthalmologic examination was carried out. The patient was found to have bilateral microphthalmia, and multifocal, moderately well-differentiated retinoblastoma in the left eye.

Original languageEnglish (US)
Pages (from-to)490-493
Number of pages4
JournalArchives of ophthalmology
Volume92
Issue number6
DOIs
StatePublished - Jan 1 1974
Externally publishedYes

Fingerprint

Chromosomes, Human, Pair 13
Retinoblastoma
Chromosome Aberrations
Chromosomes
Microphthalmos
Quinacrine
Leukocytes

ASJC Scopus subject areas

  • Ophthalmology

Cite this

Retinoblastoma and Chromosome Abnormality : Partial Deletion of the Long Arm of Chromosome 13. / Howard, Rufus O.; Breg, W. Roy; Albert, Daniel; Lesser, Robert L.

In: Archives of ophthalmology, Vol. 92, No. 6, 01.01.1974, p. 490-493.

Research output: Contribution to journalArticle

Howard, Rufus O. ; Breg, W. Roy ; Albert, Daniel ; Lesser, Robert L. / Retinoblastoma and Chromosome Abnormality : Partial Deletion of the Long Arm of Chromosome 13. In: Archives of ophthalmology. 1974 ; Vol. 92, No. 6. pp. 490-493.
@article{4e5e90b26b8b4bdabd0b3e40f670392a,
title = "Retinoblastoma and Chromosome Abnormality: Partial Deletion of the Long Arm of Chromosome 13",
abstract = "A 7-year-old girl with retarded physical and mental development was found, on chromosome determination, to have deletion of a segment of the long arm of chromosome 13 (13 q—). A precise chromosome identification was made on peripheral leukocytes by using a quinacrine banding technique. Because of previous reports of an association of the 13 q—chromosomal abnormality with retinoblastoma, an ophthalmologic examination was carried out. The patient was found to have bilateral microphthalmia, and multifocal, moderately well-differentiated retinoblastoma in the left eye.",
author = "Howard, {Rufus O.} and Breg, {W. Roy} and Daniel Albert and Lesser, {Robert L.}",
year = "1974",
month = "1",
day = "1",
doi = "10.1001/archopht.1974.01010010504007",
language = "English (US)",
volume = "92",
pages = "490--493",
journal = "JAMA Ophthalmology",
issn = "2168-6165",
publisher = "American Medical Association",
number = "6",

}

TY - JOUR

T1 - Retinoblastoma and Chromosome Abnormality

T2 - Partial Deletion of the Long Arm of Chromosome 13

AU - Howard, Rufus O.

AU - Breg, W. Roy

AU - Albert, Daniel

AU - Lesser, Robert L.

PY - 1974/1/1

Y1 - 1974/1/1

N2 - A 7-year-old girl with retarded physical and mental development was found, on chromosome determination, to have deletion of a segment of the long arm of chromosome 13 (13 q—). A precise chromosome identification was made on peripheral leukocytes by using a quinacrine banding technique. Because of previous reports of an association of the 13 q—chromosomal abnormality with retinoblastoma, an ophthalmologic examination was carried out. The patient was found to have bilateral microphthalmia, and multifocal, moderately well-differentiated retinoblastoma in the left eye.

AB - A 7-year-old girl with retarded physical and mental development was found, on chromosome determination, to have deletion of a segment of the long arm of chromosome 13 (13 q—). A precise chromosome identification was made on peripheral leukocytes by using a quinacrine banding technique. Because of previous reports of an association of the 13 q—chromosomal abnormality with retinoblastoma, an ophthalmologic examination was carried out. The patient was found to have bilateral microphthalmia, and multifocal, moderately well-differentiated retinoblastoma in the left eye.

UR - http://www.scopus.com/inward/record.url?scp=0016278606&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=0016278606&partnerID=8YFLogxK

U2 - 10.1001/archopht.1974.01010010504007

DO - 10.1001/archopht.1974.01010010504007

M3 - Article

C2 - 4433268

AN - SCOPUS:0016278606

VL - 92

SP - 490

EP - 493

JO - JAMA Ophthalmology

JF - JAMA Ophthalmology

SN - 2168-6165

IS - 6

ER -