TY - JOUR
T1 - Retinoblastoma and Chromosome Abnormality
T2 - Partial Deletion of the Long Arm of Chromosome 13
AU - Howard, Rufus O.
AU - Breg, W. Roy
AU - Albert, Daniel M.
AU - Lesser, Robert L.
PY - 1974/12
Y1 - 1974/12
N2 - A 7-year-old girl with retarded physical and mental development was found, on chromosome determination, to have deletion of a segment of the long arm of chromosome 13 (13 q—). A precise chromosome identification was made on peripheral leukocytes by using a quinacrine banding technique. Because of previous reports of an association of the 13 q—chromosomal abnormality with retinoblastoma, an ophthalmologic examination was carried out. The patient was found to have bilateral microphthalmia, and multifocal, moderately well-differentiated retinoblastoma in the left eye.
AB - A 7-year-old girl with retarded physical and mental development was found, on chromosome determination, to have deletion of a segment of the long arm of chromosome 13 (13 q—). A precise chromosome identification was made on peripheral leukocytes by using a quinacrine banding technique. Because of previous reports of an association of the 13 q—chromosomal abnormality with retinoblastoma, an ophthalmologic examination was carried out. The patient was found to have bilateral microphthalmia, and multifocal, moderately well-differentiated retinoblastoma in the left eye.
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U2 - 10.1001/archopht.1974.01010010504007
DO - 10.1001/archopht.1974.01010010504007
M3 - Article
C2 - 4433268
AN - SCOPUS:0016278606
SN - 0003-9950
VL - 92
SP - 490
EP - 493
JO - Archives of ophthalmology
JF - Archives of ophthalmology
IS - 6
ER -