Retinal optical coherence tomography at 1 μm with dynamic focus control and axial motion tracking

Michelle Cua, Sujin Lee, Dongkai Miao, Myeong Jin Ju, Paul J. Mackenzie, Yifan Jian, Marinko V. Sarunic

Research output: Contribution to journalArticle

12 Citations (Scopus)

Abstract

High-resolution optical coherence tomography (OCT) retinal imaging is important to noninvasively visualize the various retinal structures to aid in better understanding of the pathogenesis of vision-robbing diseases. However, conventional OCT systems have a trade-off between lateral resolution and depth-of-focus. In this report, we present the development of a focus-stacking OCT system with automatic focus optimization for high-resolution, extended-focal-range clinical retinal imaging by incorporating a variable-focus liquid lens into the sample arm optics. Retinal layer tracking and selection was performed using a graphics processing unit accelerated processing platform for focus optimization, providing real-time layer-specific en face visualization. After optimization, multiple volumes focused at different depths were acquired, registered, and stitched together to yield a single, high-resolution focus-stacked dataset. Using this system, we show high-resolution images of the retina and optic nerve head, from which we extracted clinically relevant parameters such as the nerve fiber layer thickness and lamina cribrosa microarchitecture.

Original languageEnglish (US)
Article number026007
JournalJournal of biomedical optics
Volume21
Issue number2
DOIs
StatePublished - Feb 1 2016
Externally publishedYes

Fingerprint

Optical tomography
tomography
Optical resolving power
high resolution
optimization
Optics
optics
nerve fibers
pathogenesis
retina
Medical imaging
nerves
Image resolution
Lenses
Visualization
platforms
lenses
Imaging techniques
Fibers
Liquids

Keywords

  • en face optical coherence tomography
  • focus-stacking
  • graphics processing unit acceleration
  • high-resolution optical coherence tomography
  • variable-focus lens

ASJC Scopus subject areas

  • Electronic, Optical and Magnetic Materials
  • Biomaterials
  • Atomic and Molecular Physics, and Optics
  • Biomedical Engineering

Cite this

Retinal optical coherence tomography at 1 μm with dynamic focus control and axial motion tracking. / Cua, Michelle; Lee, Sujin; Miao, Dongkai; Ju, Myeong Jin; Mackenzie, Paul J.; Jian, Yifan; Sarunic, Marinko V.

In: Journal of biomedical optics, Vol. 21, No. 2, 026007, 01.02.2016.

Research output: Contribution to journalArticle

Cua, Michelle ; Lee, Sujin ; Miao, Dongkai ; Ju, Myeong Jin ; Mackenzie, Paul J. ; Jian, Yifan ; Sarunic, Marinko V. / Retinal optical coherence tomography at 1 μm with dynamic focus control and axial motion tracking. In: Journal of biomedical optics. 2016 ; Vol. 21, No. 2.
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