Retinal Nerve Fiber Layer Thickness in Normal Children Measured with Optical Coherence Tomography

Daniel J. Salchow, Yuri S. Oleynikov, Michael Chiang, Shana E. Kennedy-Salchow, Kevin Langton, James C. Tsai, Lama A. Al-Aswad

Research output: Contribution to journalArticle

119 Citations (Scopus)

Abstract

Purpose: To measure the peripapillary retinal nerve fiber layer (RNFL) thickness in normal children. Design: Observational cross-sectional study. Participants: Ninety-two eyes of 92 normal children ages 4 to 17 years presenting to the Ophthalmology Clinic at the Harkness Eye Institute, Department of Ophthalmology, Columbia University. Methods: Retinal nerve fiber layer thickness was measured with optical coherence tomography (OCT). Patient cooperation and signal strength of the OCT scans were assessed. Optic disc photographs were evaluated by a glaucoma specialist in a masked fashion. Eyes with abnormal optic discs were excluded. One eye of each subject was randomly selected for statistical analysis. The effect of several factors on RNFL thickness was investigated statistically. Main Outcome Measures: Retinal nerve fiber layer thickness. Results: Ninety-one percent of the study subjects were Hispanic; 8%, African American; and 1%, Caucasian. Optical coherence tomography measurements were obtained in 117 of 121 (96.7%) subjects, and disc photographs were available for 92 of them. Mean age (±standard deviation [SD]) was 9.7±2.7 years. Mean global RNFL thickness (±SD) was 107.0±11.1 μm (range, 78.1-134.6). The RNFL was thickest inferiorly (136.9±16.9 μm) and superiorly (135.4±19.3 μm), thinner nasally (83.0±18.0 μm), and thinnest temporally (72.5±13.4 μm). In univariate regression analysis, age (P = 0.013) and refraction (P

Original languageEnglish (US)
Pages (from-to)786-791
Number of pages6
JournalOphthalmology
Volume113
Issue number5
DOIs
StatePublished - May 2006
Externally publishedYes

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Optical Coherence Tomography
Nerve Fibers
Optic Disk
Ophthalmology
Patient Compliance
Hispanic Americans
African Americans
Glaucoma
Cross-Sectional Studies
Regression Analysis
Outcome Assessment (Health Care)

ASJC Scopus subject areas

  • Ophthalmology

Cite this

Salchow, D. J., Oleynikov, Y. S., Chiang, M., Kennedy-Salchow, S. E., Langton, K., Tsai, J. C., & Al-Aswad, L. A. (2006). Retinal Nerve Fiber Layer Thickness in Normal Children Measured with Optical Coherence Tomography. Ophthalmology, 113(5), 786-791. https://doi.org/10.1016/j.ophtha.2006.01.036

Retinal Nerve Fiber Layer Thickness in Normal Children Measured with Optical Coherence Tomography. / Salchow, Daniel J.; Oleynikov, Yuri S.; Chiang, Michael; Kennedy-Salchow, Shana E.; Langton, Kevin; Tsai, James C.; Al-Aswad, Lama A.

In: Ophthalmology, Vol. 113, No. 5, 05.2006, p. 786-791.

Research output: Contribution to journalArticle

Salchow, DJ, Oleynikov, YS, Chiang, M, Kennedy-Salchow, SE, Langton, K, Tsai, JC & Al-Aswad, LA 2006, 'Retinal Nerve Fiber Layer Thickness in Normal Children Measured with Optical Coherence Tomography', Ophthalmology, vol. 113, no. 5, pp. 786-791. https://doi.org/10.1016/j.ophtha.2006.01.036
Salchow, Daniel J. ; Oleynikov, Yuri S. ; Chiang, Michael ; Kennedy-Salchow, Shana E. ; Langton, Kevin ; Tsai, James C. ; Al-Aswad, Lama A. / Retinal Nerve Fiber Layer Thickness in Normal Children Measured with Optical Coherence Tomography. In: Ophthalmology. 2006 ; Vol. 113, No. 5. pp. 786-791.
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