Retinal neoplasia and dysplasia. I. Induction by feline leukemia virus

D. M. Albert, M. Lahav, E. D. Colby, J. A. Shadduck, D. N. Sang

Research output: Contribution to journalArticlepeer-review

34 Scopus citations


Feline leukemia virus, a naturally occurring C-type virus (oncorna virus), was injected systematically and intraocularly into fetal and newborn kittens. A light microscopic study of the resultant ocular tumor changes was carried out. One animal developed an intraocular tumor of apparent retinal origin. Eight animals showed intraocular neoplastic cell infiltration. The most common ocular change observed was retinal dysplasia. Sequential histologic examination of enucleated eyes showed diffuse intraocular inflammation after viral inoculation. In the developing retinas progressive disorganization and necrosis were documented, with subsequent reorganization into cell clumps and dysplasic rosette structures. The retinal pigment epithelium showed proliferation and intraretinal migration. The mature retina exhibited full-thickness folds and tubes associated with infoldings of the retinal pigment epithelium.

Original languageEnglish (US)
Pages (from-to)325-337
Number of pages13
Issue number4
StatePublished - Dec 14 1977
Externally publishedYes

ASJC Scopus subject areas

  • Ophthalmology
  • Sensory Systems
  • Cellular and Molecular Neuroscience


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