Retinal neoplasia and dysplasia. I. Induction by feline leukemia virus

D. M. Albert; M. Lahav; E. D. Colby; J. A. Shadduck; D. N. Sang

Retinal neoplasia and dysplasia. I. Induction by feline leukemia virus

D. M. Albert, M. Lahav, E. D. Colby, J. A. Shadduck, D. N. Sang

Research output: Contribution to journal › Article › peer-review

Abstract

Feline leukemia virus, a naturally occurring C-type virus (oncorna virus), was injected systematically and intraocularly into fetal and newborn kittens. A light microscopic study of the resultant ocular tumor changes was carried out. One animal developed an intraocular tumor of apparent retinal origin. Eight animals showed intraocular neoplastic cell infiltration. The most common ocular change observed was retinal dysplasia. Sequential histologic examination of enucleated eyes showed diffuse intraocular inflammation after viral inoculation. In the developing retinas progressive disorganization and necrosis were documented, with subsequent reorganization into cell clumps and dysplasic rosette structures. The retinal pigment epithelium showed proliferation and intraretinal migration. The mature retina exhibited full-thickness folds and tubes associated with infoldings of the retinal pigment epithelium.

Original language	English (US)
Pages (from-to)	325-337
Number of pages	13
Journal	INVEST.OPHTHAL.VISUAL SCI.
Volume	16
Issue number	4
State	Published - Dec 14 1977
Externally published	Yes

ASJC Scopus subject areas

Ophthalmology
Sensory Systems
Cellular and Molecular Neuroscience

Cite this

@article{4e5f261427044bf280354efbde290131,

title = "Retinal neoplasia and dysplasia. I. Induction by feline leukemia virus",

abstract = "Feline leukemia virus, a naturally occurring C-type virus (oncorna virus), was injected systematically and intraocularly into fetal and newborn kittens. A light microscopic study of the resultant ocular tumor changes was carried out. One animal developed an intraocular tumor of apparent retinal origin. Eight animals showed intraocular neoplastic cell infiltration. The most common ocular change observed was retinal dysplasia. Sequential histologic examination of enucleated eyes showed diffuse intraocular inflammation after viral inoculation. In the developing retinas progressive disorganization and necrosis were documented, with subsequent reorganization into cell clumps and dysplasic rosette structures. The retinal pigment epithelium showed proliferation and intraretinal migration. The mature retina exhibited full-thickness folds and tubes associated with infoldings of the retinal pigment epithelium.",

author = "Albert, {D. M.} and M. Lahav and Colby, {E. D.} and Shadduck, {J. A.} and Sang, {D. N.}",

year = "1977",

month = dec,

day = "14",

language = "English (US)",

volume = "16",

pages = "325--337",

journal = "Investigative Ophthalmology and Visual Science",

issn = "0146-0404",

publisher = "Association for Research in Vision and Ophthalmology Inc.",

number = "4",

}

TY - JOUR

T1 - Retinal neoplasia and dysplasia. I. Induction by feline leukemia virus

AU - Albert, D. M.

AU - Lahav, M.

AU - Colby, E. D.

AU - Shadduck, J. A.

AU - Sang, D. N.

PY - 1977/12/14

Y1 - 1977/12/14

N2 - Feline leukemia virus, a naturally occurring C-type virus (oncorna virus), was injected systematically and intraocularly into fetal and newborn kittens. A light microscopic study of the resultant ocular tumor changes was carried out. One animal developed an intraocular tumor of apparent retinal origin. Eight animals showed intraocular neoplastic cell infiltration. The most common ocular change observed was retinal dysplasia. Sequential histologic examination of enucleated eyes showed diffuse intraocular inflammation after viral inoculation. In the developing retinas progressive disorganization and necrosis were documented, with subsequent reorganization into cell clumps and dysplasic rosette structures. The retinal pigment epithelium showed proliferation and intraretinal migration. The mature retina exhibited full-thickness folds and tubes associated with infoldings of the retinal pigment epithelium.

AB - Feline leukemia virus, a naturally occurring C-type virus (oncorna virus), was injected systematically and intraocularly into fetal and newborn kittens. A light microscopic study of the resultant ocular tumor changes was carried out. One animal developed an intraocular tumor of apparent retinal origin. Eight animals showed intraocular neoplastic cell infiltration. The most common ocular change observed was retinal dysplasia. Sequential histologic examination of enucleated eyes showed diffuse intraocular inflammation after viral inoculation. In the developing retinas progressive disorganization and necrosis were documented, with subsequent reorganization into cell clumps and dysplasic rosette structures. The retinal pigment epithelium showed proliferation and intraretinal migration. The mature retina exhibited full-thickness folds and tubes associated with infoldings of the retinal pigment epithelium.

UR - http://www.scopus.com/inward/record.url?scp=0017364476&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=0017364476&partnerID=8YFLogxK

M3 - Article

C2 - 191424

AN - SCOPUS:0017364476

SN - 0146-0404

VL - 16

SP - 325

EP - 337

JO - Investigative Ophthalmology and Visual Science

JF - Investigative Ophthalmology and Visual Science

IS - 4

ER -

Retinal neoplasia and dysplasia. I. Induction by feline leukemia virus

Abstract

ASJC Scopus subject areas

Other files and links

Fingerprint

Cite this