Retinal morphology and visual pigment levels in 6- and 12-month-old rhesus monkeys fed a taurine-free human infant formula

H. Imaki, S. G. Jacobson, C. M. Kemp, R. W. Knighton, Martha Neuringer, J. Sturman

    Research output: Contribution to journalArticle

    21 Citations (Scopus)

    Abstract

    Rhesus monkey infants were raised from birth until 6 or 12 months of age on a taurine-free soy protein-based human infant formula or on the same formula supplemented with taurine. An additional group received taurine-free formula until 6 months and then the supplemented diet from 6 until 12 months. The densities of rod and cone visual pigments were measured by fundus reflectometry at 6 and 12 months, and retinal morphology was then examined by light and electron microscopy. The densities of rhodopsin, measured in the near periphery after a white bleach, and of cone pigment, measured in the macula after a red bleach, were significantly reduced in the taurine-deprived monkeys at 6 months but not at 12 months. The retinas of 6-month-old taurine- deprived infants showed degenerative morphological changes in photoreceptors, particularly in cones in the foveal region, which were somewhat less severe than those seen in a previous study at 3 months of age. The prevalence and degree of these abnormalities continued to decrease with age in taurine- deprived animals, but changes persisted in some animals at 12 months. Recovery was more complete in monkeys reversed to the supplemented diet from 6 to 12 months. Thus, monkey infants are dependent on dietary taurine to maintain normal retinal structure until at least 6 months of age; the effects of taurine deprivation regress spontaneously but incompletely by 12 months.

    Original languageEnglish (US)
    Pages (from-to)290-304
    Number of pages15
    JournalJournal of Neuroscience Research
    Volume36
    Issue number3
    DOIs
    StatePublished - 1993

    Fingerprint

    Infant Formula
    Retinal Pigments
    Taurine
    Macaca mulatta
    Haplorhini
    Diet
    Vertebrate Photoreceptor Cells
    Soybean Proteins
    Rhodopsin
    Retina
    Electron Microscopy
    Parturition
    Light

    Keywords

    • infant nutrition
    • photoreceptors
    • retina
    • retinal degeneration
    • rhodopsin
    • taurine- deprived monkeys

    ASJC Scopus subject areas

    • Neuroscience(all)

    Cite this

    Retinal morphology and visual pigment levels in 6- and 12-month-old rhesus monkeys fed a taurine-free human infant formula. / Imaki, H.; Jacobson, S. G.; Kemp, C. M.; Knighton, R. W.; Neuringer, Martha; Sturman, J.

    In: Journal of Neuroscience Research, Vol. 36, No. 3, 1993, p. 290-304.

    Research output: Contribution to journalArticle

    Imaki, H. ; Jacobson, S. G. ; Kemp, C. M. ; Knighton, R. W. ; Neuringer, Martha ; Sturman, J. / Retinal morphology and visual pigment levels in 6- and 12-month-old rhesus monkeys fed a taurine-free human infant formula. In: Journal of Neuroscience Research. 1993 ; Vol. 36, No. 3. pp. 290-304.
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