Retinal Manifestations of Neurofibromatosis: Diagnosis and Management

Maryanna Destro; Donald J. D'amico; Evangelos S. Gragoudas; Robert J. Brockhurst; Michael K. Pinnolis; Daniel M. Albert; Trexler M. Topping; Carmen A. Puliafito

doi:10.1001/archopht.1991.01080050076033

Retinal Manifestations of Neurofibromatosis: Diagnosis and Management

Maryanna Destro, Donald J. D'amico, Evangelos S. Gragoudas, Robert J. Brockhurst, Michael K. Pinnolis, Daniel M. Albert, Trexler M. Topping, Carmen A. Puliafito

Research output: Contribution to journal › Article › peer-review

103 Scopus citations

Abstract

Five patients presented with vision-threatening retinal tumors and systemic signs of neurofibromatosis, including neurofibromatosis type 1 (four patients) and familial cafe-au-lait spots (one patient). These tumors included large retinal astrocytic hamartomas, multiple retinal capillary hemangiomas, and combined hamartomas of the retina and retinal pigment epithelium, which resulted in rubeotic glaucoma, vitreous hemorrhage, and retinal detachment. Surgical therapy included retinal cryopexy, xenon and argon photocoagulation, scleral buckling, and pars plana vitrectomy with excisional retinal biopsy. Retinal tumors may result in marked visual loss in patients with neurofibromatosis, and vitreoretinal surgery may restore useful vision in some of these patients.

Original language	English (US)
Pages (from-to)	662-666
Number of pages	5
Journal	Archives of ophthalmology
Volume	109
Issue number	5
DOIs	https://doi.org/10.1001/archopht.1991.01080050076033
State	Published - May 1991
Externally published	Yes

ASJC Scopus subject areas

Ophthalmology

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10.1001/archopht.1991.01080050076033

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title = "Retinal Manifestations of Neurofibromatosis: Diagnosis and Management",

abstract = "Five patients presented with vision-threatening retinal tumors and systemic signs of neurofibromatosis, including neurofibromatosis type 1 (four patients) and familial cafe-au-lait spots (one patient). These tumors included large retinal astrocytic hamartomas, multiple retinal capillary hemangiomas, and combined hamartomas of the retina and retinal pigment epithelium, which resulted in rubeotic glaucoma, vitreous hemorrhage, and retinal detachment. Surgical therapy included retinal cryopexy, xenon and argon photocoagulation, scleral buckling, and pars plana vitrectomy with excisional retinal biopsy. Retinal tumors may result in marked visual loss in patients with neurofibromatosis, and vitreoretinal surgery may restore useful vision in some of these patients.",

author = "Maryanna Destro and D'amico, {Donald J.} and Gragoudas, {Evangelos S.} and Brockhurst, {Robert J.} and Pinnolis, {Michael K.} and Albert, {Daniel M.} and Topping, {Trexler M.} and Puliafito, {Carmen A.}",

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AU - Destro, Maryanna

AU - D'amico, Donald J.

AU - Gragoudas, Evangelos S.

AU - Brockhurst, Robert J.

AU - Pinnolis, Michael K.

AU - Albert, Daniel M.

AU - Topping, Trexler M.

AU - Puliafito, Carmen A.

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AB - Five patients presented with vision-threatening retinal tumors and systemic signs of neurofibromatosis, including neurofibromatosis type 1 (four patients) and familial cafe-au-lait spots (one patient). These tumors included large retinal astrocytic hamartomas, multiple retinal capillary hemangiomas, and combined hamartomas of the retina and retinal pigment epithelium, which resulted in rubeotic glaucoma, vitreous hemorrhage, and retinal detachment. Surgical therapy included retinal cryopexy, xenon and argon photocoagulation, scleral buckling, and pars plana vitrectomy with excisional retinal biopsy. Retinal tumors may result in marked visual loss in patients with neurofibromatosis, and vitreoretinal surgery may restore useful vision in some of these patients.

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Retinal Manifestations of Neurofibromatosis: Diagnosis and Management

Abstract

ASJC Scopus subject areas

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