Retinal Manifestations of Neurofibromatosis: Diagnosis and Management

Maryanna Destro, Donald J. D'amico, Evangelos S. Gragoudas, Robert J. Brockhurst, Michael K. Pinnolis, Daniel Albert, Trexler M. Topping, Carmen A. Puliafito

Research output: Contribution to journalArticle

82 Citations (Scopus)

Abstract

Five patients presented with vision-threatening retinal tumors and systemic signs of neurofibromatosis, including neurofibromatosis type 1 (four patients) and familial cafe-au-lait spots (one patient). These tumors included large retinal astrocytic hamartomas, multiple retinal capillary hemangiomas, and combined hamartomas of the retina and retinal pigment epithelium, which resulted in rubeotic glaucoma, vitreous hemorrhage, and retinal detachment. Surgical therapy included retinal cryopexy, xenon and argon photocoagulation, scleral buckling, and pars plana vitrectomy with excisional retinal biopsy. Retinal tumors may result in marked visual loss in patients with neurofibromatosis, and vitreoretinal surgery may restore useful vision in some of these patients.

Original languageEnglish (US)
Pages (from-to)662-666
Number of pages5
JournalArchives of ophthalmology
Volume109
Issue number5
DOIs
StatePublished - Jan 1 1991
Externally publishedYes

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Neurofibromatoses
Retinal Neoplasms
Hamartoma
Cafe-au-Lait Spots
Capillary Hemangioma
Vitreous Detachment
Vitreoretinal Surgery
Scleral Buckling
Vitreous Hemorrhage
Xenon
Neurofibromatosis 1
Temazepam
Retinal Pigment Epithelium
Light Coagulation
Argon
Vitrectomy
Retinal Detachment
Glaucoma
Retina
Biopsy

ASJC Scopus subject areas

  • Ophthalmology

Cite this

Destro, M., D'amico, D. J., Gragoudas, E. S., Brockhurst, R. J., Pinnolis, M. K., Albert, D., ... Puliafito, C. A. (1991). Retinal Manifestations of Neurofibromatosis: Diagnosis and Management. Archives of ophthalmology, 109(5), 662-666. https://doi.org/10.1001/archopht.1991.01080050076033

Retinal Manifestations of Neurofibromatosis : Diagnosis and Management. / Destro, Maryanna; D'amico, Donald J.; Gragoudas, Evangelos S.; Brockhurst, Robert J.; Pinnolis, Michael K.; Albert, Daniel; Topping, Trexler M.; Puliafito, Carmen A.

In: Archives of ophthalmology, Vol. 109, No. 5, 01.01.1991, p. 662-666.

Research output: Contribution to journalArticle

Destro, M, D'amico, DJ, Gragoudas, ES, Brockhurst, RJ, Pinnolis, MK, Albert, D, Topping, TM & Puliafito, CA 1991, 'Retinal Manifestations of Neurofibromatosis: Diagnosis and Management', Archives of ophthalmology, vol. 109, no. 5, pp. 662-666. https://doi.org/10.1001/archopht.1991.01080050076033
Destro, Maryanna ; D'amico, Donald J. ; Gragoudas, Evangelos S. ; Brockhurst, Robert J. ; Pinnolis, Michael K. ; Albert, Daniel ; Topping, Trexler M. ; Puliafito, Carmen A. / Retinal Manifestations of Neurofibromatosis : Diagnosis and Management. In: Archives of ophthalmology. 1991 ; Vol. 109, No. 5. pp. 662-666.
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