TY - JOUR
T1 - Retinal degeneration in primates raised on a synthetic human infant formula
AU - Sturman, John A.
AU - Wen, Guang Y.
AU - Wisniewski, Henryk M.
AU - Neuringer, Martha D.
N1 - Funding Information:
Acknowledgements--These studies were supported by grants from N IH (H D-11129 to J.A,S. and RR-00163 to the Oregon Regional Primate Research Center) and by the Office of Mental Retardation and Developmental Disabilities of the State of New York. We thank Mr. Richard Weed for expert photography.
PY - 1984
Y1 - 1984
N2 - A degeneration of the retinal cone photoreceptor cells, but not of the rod photoreceptor cells, is present in rhesus monkeys raised from birth for 26 months on a commercially available human infant protein hydrolyzate formula. This degeneration is associated with a selective decrease in plasma taurine concentration, and is entirely prevented by supplementing the formula with taurine. A reduced conedominated ERG was present at 10 months, but not at 18 or 26 months. These results suggest that the implications of the reduced taurine concentrations in human infants fed synthetic formulas containing little or no taurine should be reconsidered, since adverse effects on the visual system may only be detectable at the ultrastructural level.
AB - A degeneration of the retinal cone photoreceptor cells, but not of the rod photoreceptor cells, is present in rhesus monkeys raised from birth for 26 months on a commercially available human infant protein hydrolyzate formula. This degeneration is associated with a selective decrease in plasma taurine concentration, and is entirely prevented by supplementing the formula with taurine. A reduced conedominated ERG was present at 10 months, but not at 18 or 26 months. These results suggest that the implications of the reduced taurine concentrations in human infants fed synthetic formulas containing little or no taurine should be reconsidered, since adverse effects on the visual system may only be detectable at the ultrastructural level.
KW - Infant formula
KW - Retinal degeneration
KW - Taurine
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U2 - 10.1016/0736-5748(84)90003-0
DO - 10.1016/0736-5748(84)90003-0
M3 - Article
AN - SCOPUS:0021266263
SN - 0736-5748
VL - 2
SP - 121
EP - 129
JO - International Journal of Developmental Neuroscience
JF - International Journal of Developmental Neuroscience
IS - 2
ER -