Retinal degeneration in 3‐month‐old rhesus monkey infants fed a taurine‐free human infant formula

H. Imaki, R. Moretz, H. Wisniewski, M. Neuringer, J. Sturman

    Research output: Contribution to journalArticle

    43 Scopus citations

    Abstract

    Rhesus monkey infants were raised from birth on a taurine‐free soy protein‐based human infant formula or on the same formula supplemented with taurine. The monkeys were killed 3 months after birth and the retinas examined by light and electron microscopy. All of the monkeys raised on formula alone showed degenerative ultrastructural changes in photoreceptor outer segments that ranged froom swelling and disorientation to fragmentation and disorganiozation. Cones were more severely affected than rods, and changes were most pronounced in the foveal region. Changes were also noted ion the fine structure of the retinal pigment epithelium. These changes were prevented in all but one monkey fed the same formula supplemented with taurine. These results provide further support for the addition of taurine to commercial human infant formulas.

    Original languageEnglish (US)
    Pages (from-to)602-614
    Number of pages13
    JournalJournal of Neuroscience Research
    Volume18
    Issue number4
    DOIs
    StatePublished - 1987

    Keywords

    • cones
    • nutritional taurine
    • primate photoreceptors
    • retina
    • rods
    • taurine‐deprivation

    ASJC Scopus subject areas

    • Cellular and Molecular Neuroscience

    Fingerprint Dive into the research topics of 'Retinal degeneration in 3‐month‐old rhesus monkey infants fed a taurine‐free human infant formula'. Together they form a unique fingerprint.

  • Cite this