Retinal blood flow measurement by circumpapillary Fourier domain Doppler optical coherence tomography

Yimin Wang, Bradley A. Bower, Joseph A. Izatt, Ou Tan, David Huang

Research output: Contribution to journalArticle

127 Citations (Scopus)

Abstract

We present in vivo human total retinal blood flow measurements using Doppler Fourier domain optical coherence tomography (OCT). The scan pattern consisted of two concentric circles around the optic nerve head, transecting all retinal branch arteries and veins. The relative positions of each blood vessel in the two OCT conic cross sections were measured and used to determine the angle between the OCT beam and the vessel. The measured angle and the Doppler shift profile were used to compute blood flow in the blood vessel. The flows in the branch veins was summed to give the total retinal blood flow at one time point. Each measurement of total retinal blood flow was completed within 2s and averaged. The total retinal venous flow was measured in one eye each of two volunteers. The results were 52.90±2.75 and 45.23±3.18 μl/min, respectively. Volumetric flow rate positively correlated with vessel diameter. This new technique may be useful in the diagnosis and treatment of optic nerve and retinal diseases that are associated with poor blood flow, such as glaucoma and diabetic retinopathy.

Original languageEnglish (US)
Article number064003
JournalJournal of Biomedical Optics
Volume13
Issue number6
DOIs
StatePublished - 2008
Externally publishedYes

Fingerprint

Optical tomography
flow measurement
Flow measurement
blood flow
Blood
tomography
blood vessels
Blood vessels
nerves
veins
vessels
Optics
glaucoma
optics
Doppler effect
arteries
flow velocity
Flow rate
shift
cross sections

Keywords

  • Flow diagnostics
  • Medical and biological imaging
  • Ophthalmology
  • Optical coherence tomography

ASJC Scopus subject areas

  • Biomedical Engineering
  • Biomaterials
  • Electronic, Optical and Magnetic Materials
  • Atomic and Molecular Physics, and Optics

Cite this

Retinal blood flow measurement by circumpapillary Fourier domain Doppler optical coherence tomography. / Wang, Yimin; Bower, Bradley A.; Izatt, Joseph A.; Tan, Ou; Huang, David.

In: Journal of Biomedical Optics, Vol. 13, No. 6, 064003, 2008.

Research output: Contribution to journalArticle

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