TY - JOUR
T1 - Reticular Pseudodrusen Characteristics and Associations in the Carotenoids in Age-Related Eye Disease Study 2 (CAREDS2), an Ancillary Study of the Women's Health Initiative
AU - Second Carotenoids in Age-Related Eye Disease Study Investigators
AU - Cleland, Spencer C.
AU - Domalpally, Amitha
AU - Liu, Zhe
AU - Pak, Jeong W.
AU - Blodi, Barbara A.
AU - Bailey, Steven
AU - Gehrs, Karen
AU - Wallace, Robert
AU - Tinker, Lesley
AU - Mares, Julie A.
AU - Mares, Julie
AU - Blodi, Barbara
AU - Liu, Yao
AU - Engelman, Corinne
AU - Gangnon, Ronald
AU - Sarto, Gloria
AU - LeBlanc, Erin
AU - Robinson, Jennifer
AU - Snodderly, D. Max
AU - Hammond, Randy
AU - Millen, Amy
AU - Johnson, Elizabeth
AU - Wooten, Bill
AU - Maykoski, Jennifer
AU - Lundquist, Ann
AU - Smith, Chris
AU - Wood, Kim
AU - Perry-Raymond, Jennie
AU - Stockman, Heather
AU - Walshire, Jean
AU - Sinkey, Christine
AU - Lawler, Thomas
AU - Blomme, Courtney
AU - Hall, Kristen
AU - Pauk, Diane
AU - Alexander, Sherri
AU - Mezhibovsky, Esther
AU - Christensen, Krista
AU - Nalbandyan, Marine
N1 - Publisher Copyright:
© 2020 American Academy of Ophthalmology
PY - 2021/8
Y1 - 2021/8
N2 - Purpose: To determine the prevalence and morphologic features of reticular pseudodrusen (RPD) and their association with participant demographics and age-related macular degeneration (AMD) status in the Carotenoids in Age-Related Eye Disease Study 2 (CAREDS2) sample, an ancillary study of the Women's Health Initiative Observational Study. Design: Cross-sectional, multicenter, natural history study. Participants: Nine hundred and twenty-seven eyes from 466 postmenopausal women 69 to 101 years of age. Methods: Multimodal imaging, including spectral-domain (SD) OCT and infrared reflectance (IR), were used to identify RPD characteristics, including location (within or outside the 6-mm diameter circle centered at the macula), presence of peripapillary RPD, pattern of RPD, and RPD area. Age-related macular degeneration features from SD OCT, IR, and color photographs also were assessed and AMD severity was categorized. Main Outcome Measures: Reticular pseudodrusen prevalence using SD OCT and IR imaging and AMD status. Results: Reticular pseudodrusen were present in 130 eyes (14% of eyes, 16% of participants), with increasing prevalence with age: 7% in those younger than 78 years, 14% in those 78 to 83 years of age, and 30% in those older than 83 years. Using clinical classification of AMD with color photography, RPD were seen in 2.4% of eyes with no AMD or aging changes, 11.5% in early AMD, 25.1% in intermediate AMD, and 51.1% in late AMD. Mean RPD area was 17.4 mm2 (standard deviation, 14.7 mm2). Ribbon morphologic RPD (53%) was more common than dot morphologic RPD (36%). Reticular pseudodrusen mostly were located both within and outside the 6-mm circle with primarily superior retinal distribution. Reticular pseudodrusen were visualized with corresponding color fundus photography in only 38 eyes (4% of total eyes). Participants with and without RPD had a visual acuity±standard error of 77.9 ± 1.4 letters and 81.3 ± 0.4 letters, respectively (P = 0.02). Conclusions: The prevalence of RPD in CAREDS2 increased with age and was associated with AMD severity. Reticular pseudodrusen were detected in eyes without other features of AMD and could represent an earlier disease state. Multimodal imaging with SD OCT and IR has significantly greater sensitivity for visualizing RPD than color fundus photography.
AB - Purpose: To determine the prevalence and morphologic features of reticular pseudodrusen (RPD) and their association with participant demographics and age-related macular degeneration (AMD) status in the Carotenoids in Age-Related Eye Disease Study 2 (CAREDS2) sample, an ancillary study of the Women's Health Initiative Observational Study. Design: Cross-sectional, multicenter, natural history study. Participants: Nine hundred and twenty-seven eyes from 466 postmenopausal women 69 to 101 years of age. Methods: Multimodal imaging, including spectral-domain (SD) OCT and infrared reflectance (IR), were used to identify RPD characteristics, including location (within or outside the 6-mm diameter circle centered at the macula), presence of peripapillary RPD, pattern of RPD, and RPD area. Age-related macular degeneration features from SD OCT, IR, and color photographs also were assessed and AMD severity was categorized. Main Outcome Measures: Reticular pseudodrusen prevalence using SD OCT and IR imaging and AMD status. Results: Reticular pseudodrusen were present in 130 eyes (14% of eyes, 16% of participants), with increasing prevalence with age: 7% in those younger than 78 years, 14% in those 78 to 83 years of age, and 30% in those older than 83 years. Using clinical classification of AMD with color photography, RPD were seen in 2.4% of eyes with no AMD or aging changes, 11.5% in early AMD, 25.1% in intermediate AMD, and 51.1% in late AMD. Mean RPD area was 17.4 mm2 (standard deviation, 14.7 mm2). Ribbon morphologic RPD (53%) was more common than dot morphologic RPD (36%). Reticular pseudodrusen mostly were located both within and outside the 6-mm circle with primarily superior retinal distribution. Reticular pseudodrusen were visualized with corresponding color fundus photography in only 38 eyes (4% of total eyes). Participants with and without RPD had a visual acuity±standard error of 77.9 ± 1.4 letters and 81.3 ± 0.4 letters, respectively (P = 0.02). Conclusions: The prevalence of RPD in CAREDS2 increased with age and was associated with AMD severity. Reticular pseudodrusen were detected in eyes without other features of AMD and could represent an earlier disease state. Multimodal imaging with SD OCT and IR has significantly greater sensitivity for visualizing RPD than color fundus photography.
KW - Age-related macular degeneration
KW - Carotenoids in Age-Related Eye Disease Study 2
KW - Optical coherence tomography
KW - Reticular pseudodrusen
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UR - http://www.scopus.com/inward/citedby.url?scp=85105801331&partnerID=8YFLogxK
U2 - 10.1016/j.oret.2020.12.019
DO - 10.1016/j.oret.2020.12.019
M3 - Article
C2 - 33387684
AN - SCOPUS:85105801331
SN - 2468-7219
VL - 5
SP - 721
EP - 729
JO - Ophthalmology Retina
JF - Ophthalmology Retina
IS - 8
ER -