Results of an abbreviated phase II study of AKT inhibitor MK-2206 in the treatment of recurrent platinum-resistant high grade serous ovarian, fallopian tube, or primary peritoneal carcinoma (NCT 01283035)

Elizabeth K. Lee, Zhenying Tan-Wasielewski, Carol Aghajanian, Robert L. Coleman, Jennifer Curtis, Michelle S. Hirsch, Ursula A. Matulonis, Lewis C. Cantley, Gordon B. Mills, L. Austin Doyle, Joyce F. Liu

    Research output: Contribution to journalArticle

    Abstract

    Platinum-resistant, recurrent, high grade epithelial ovarian carcinoma remains challenging to treat. Chemotherapy produces limited responses with modest survival benefits in the treatment of recurrent disease. In this context, targeted therapies may improve upon conventional therapies. PI3K/AKT pathway alterations are frequently found in several cancer types, including ovarian cancer, and thus AKT inhibition is a rational targeted therapy. Here we report the results of an abbreviated trial of AKT inhibitor MK-2206 in platinum resistant high grade serous ovarian, fallopian tube, and primary peritoneal cancer with PTEN loss.

    Original languageEnglish (US)
    Article number100546
    JournalGynecologic Oncology Reports
    Volume32
    DOIs
    StatePublished - May 2020

      Fingerprint

    Keywords

    • AKT inhibitor
    • MK-2206
    • PI3K/AKT pathway
    • Platinum resistant ovarian cancer
    • PTEN
    • Serous ovarian carcinoma

    ASJC Scopus subject areas

    • Oncology
    • Obstetrics and Gynecology

    Cite this