Restriction of placental vasculature in a non-human primate: A unique model to study placental plasticity

V. H.J. Roberts, J. P. Räsänen, M. J. Novy, A. Frias, S. Louey, T. K. Morgan, K. L. Thornburg, E. R. Spindel, P. L. Grigsby

Research output: Contribution to journalArticle

27 Scopus citations

Abstract

The limits of placental plasticity, i.e., the ability of the placenta to adapt and alter its growth trajectory in response to altered fetal requirements, are not known. We report fetal and placental hemodynamic adaptations in a novel non-human primate model in which the fetal inter-placental bridging vessels were surgically ligated. Doppler ultrasound studies showed that the rhesus placenta compensates for an approximate 40% reduction in functional capacity by increased growth and maintenance of umbilical volume blood flow. This unique experimental animal model has applications for mechanistic studies of placental plasticity and the impact on fetal development.

Original languageEnglish (US)
Pages (from-to)73-76
Number of pages4
JournalPlacenta
Volume33
Issue number1
DOIs
StatePublished - Jan 2012

Keywords

  • Developmental programming
  • Fetal growth restriction
  • Feto-placental blood flow
  • Non-human primate
  • Placental plasticity

ASJC Scopus subject areas

  • Reproductive Medicine
  • Obstetrics and Gynecology
  • Developmental Biology

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