Restricting apoptosis for postmitotic cell survival and its relevance to cancer

Kevin Wright, Mohanish Deshmukh

Research output: Contribution to journalArticle

28 Citations (Scopus)

Abstract

The importance of apoptosis in multicellular organisms is signified by the high degree of genetic conservation in the core components of this pathway from C. elegans through mammals. However, as the cells which comprise these organisms have diversified and become more specialized, so have the mechanisms which regulate the apoptotic pathway. The complex regulatory mechanisms by which the apoptotic pathway is refined are perhaps most apparent in differentiated postmitotic cells such as neurons, cardiomyocytes, and skeletal myotubes. The lack of significant regenerative potential in postmitotic cells demands that they must persist long-term, often for the full lifespan of an organism. Recent studies have identified several diverse mechanisms by which postmitotic cells restrict their apoptotic potential. Importantly, these mechanisms may also be coopted by cancer cells in order to evade apoptosis.

Original languageEnglish (US)
Pages (from-to)1616-1620
Number of pages5
JournalCell Cycle
Volume5
Issue number15
StatePublished - Aug 1 2006
Externally publishedYes

Fingerprint

Cell Survival
Cells
Apoptosis
Mammals
Neurons
Conservation
Neoplasms
Skeletal Muscle Fibers
Cardiac Myocytes

Keywords

  • Apoptosis
  • ARC
  • Bax
  • Cancer
  • Cardiomyocytes
  • Caspases
  • Cytochrome c
  • IAPs
  • Myotubes
  • Neurons

ASJC Scopus subject areas

  • Cell Biology
  • Biochemistry
  • Molecular Biology

Cite this

Restricting apoptosis for postmitotic cell survival and its relevance to cancer. / Wright, Kevin; Deshmukh, Mohanish.

In: Cell Cycle, Vol. 5, No. 15, 01.08.2006, p. 1616-1620.

Research output: Contribution to journalArticle

Wright, Kevin ; Deshmukh, Mohanish. / Restricting apoptosis for postmitotic cell survival and its relevance to cancer. In: Cell Cycle. 2006 ; Vol. 5, No. 15. pp. 1616-1620.
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