Restricted replication of xenotropic murine leukemia virus-related virus in pigtailed macaques

Gregory Q. Del Prete, Mary F. Kearney, Jon Spindler, Ann Wiegand, Elena Chertova, James D. Roser, Jacob Estes, Xing Pei Hao, Charles M. Trubey, Abigail Lara, KyeongEun Lee, Chawaree Chaipan, Julian W. Bess, Kunio Nagashima, Brandon F. Keele, Rhonda MacAllister, Jeremy Smedley, Vinay K. Pathak, Vineet N. KewalRamani, John M. CoffinJeffrey D. Lifson

Research output: Contribution to journalArticle

15 Citations (Scopus)

Abstract

Although xenotropic murine leukemia virus-related virus (XMRV) has been previously linked to prostate cancer and myalgic encephalomyelitis/chronic fatigue syndrome, recent data indicate that results interpreted as evidence of human XMRV infection reflect laboratory contamination rather than authentic in vivo infection. Nevertheless, XMRV is a retrovirus of undefined pathogenic potential that is able to replicate in human cells. Here we describe a comprehensive analysis of two male pigtailed macaques (Macaca nemestrina) experimentally infected with XMRV. Following intravenous inoculation with>1010 RNA copy equivalents of XMRV, viral replication was limited and transient, peaking at

Original languageEnglish (US)
Pages (from-to)3152-3166
Number of pages15
JournalJournal of Virology
Volume86
Issue number6
DOIs
StatePublished - Mar 2012
Externally publishedYes

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Xenotropic murine leukemia virus-related virus
Gammaretrovirus
Macaca nemestrina
Macaca
viruses
Chronic Fatigue Syndrome
Retroviridae
prostatic neoplasms
Virus Diseases
encephalitis
Virus Replication
virus replication
infection
Prostatic Neoplasms
pathogenicity
RNA
Infection

ASJC Scopus subject areas

  • Immunology
  • Virology

Cite this

Del Prete, G. Q., Kearney, M. F., Spindler, J., Wiegand, A., Chertova, E., Roser, J. D., ... Lifson, J. D. (2012). Restricted replication of xenotropic murine leukemia virus-related virus in pigtailed macaques. Journal of Virology, 86(6), 3152-3166. https://doi.org/10.1128/JVI.06886-11

Restricted replication of xenotropic murine leukemia virus-related virus in pigtailed macaques. / Del Prete, Gregory Q.; Kearney, Mary F.; Spindler, Jon; Wiegand, Ann; Chertova, Elena; Roser, James D.; Estes, Jacob; Hao, Xing Pei; Trubey, Charles M.; Lara, Abigail; Lee, KyeongEun; Chaipan, Chawaree; Bess, Julian W.; Nagashima, Kunio; Keele, Brandon F.; MacAllister, Rhonda; Smedley, Jeremy; Pathak, Vinay K.; KewalRamani, Vineet N.; Coffin, John M.; Lifson, Jeffrey D.

In: Journal of Virology, Vol. 86, No. 6, 03.2012, p. 3152-3166.

Research output: Contribution to journalArticle

Del Prete, GQ, Kearney, MF, Spindler, J, Wiegand, A, Chertova, E, Roser, JD, Estes, J, Hao, XP, Trubey, CM, Lara, A, Lee, K, Chaipan, C, Bess, JW, Nagashima, K, Keele, BF, MacAllister, R, Smedley, J, Pathak, VK, KewalRamani, VN, Coffin, JM & Lifson, JD 2012, 'Restricted replication of xenotropic murine leukemia virus-related virus in pigtailed macaques', Journal of Virology, vol. 86, no. 6, pp. 3152-3166. https://doi.org/10.1128/JVI.06886-11
Del Prete GQ, Kearney MF, Spindler J, Wiegand A, Chertova E, Roser JD et al. Restricted replication of xenotropic murine leukemia virus-related virus in pigtailed macaques. Journal of Virology. 2012 Mar;86(6):3152-3166. https://doi.org/10.1128/JVI.06886-11
Del Prete, Gregory Q. ; Kearney, Mary F. ; Spindler, Jon ; Wiegand, Ann ; Chertova, Elena ; Roser, James D. ; Estes, Jacob ; Hao, Xing Pei ; Trubey, Charles M. ; Lara, Abigail ; Lee, KyeongEun ; Chaipan, Chawaree ; Bess, Julian W. ; Nagashima, Kunio ; Keele, Brandon F. ; MacAllister, Rhonda ; Smedley, Jeremy ; Pathak, Vinay K. ; KewalRamani, Vineet N. ; Coffin, John M. ; Lifson, Jeffrey D. / Restricted replication of xenotropic murine leukemia virus-related virus in pigtailed macaques. In: Journal of Virology. 2012 ; Vol. 86, No. 6. pp. 3152-3166.
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