Resting state functional connectivity of the nucleus accumbens in youth with a family history of alcoholism

Anita Cservenka, Kaitlyn Casimo, Damien Fair, Bonnie Nagel

Research output: Contribution to journalArticle

45 Citations (Scopus)

Abstract

Adolescents with a family history of alcoholism (FHP) are at heightened risk for developing alcohol use disorders (AUDs). The nucleus accumbens (NAcc), a key brain region for reward processing, is implicated in the development of AUDs. Thus, functional connectivity of the NAcc may be an important marker of risk in FHP youth. Resting state functional magnetic resonance imaging (rs-fcMRI) was used to examine the intrinsic connectivity of the NAcc in 47 FHP and 50 family history negative (FHN) youth, ages 10-16 years old. FHP and FHN adolescents showed significant group differences in resting state synchrony between the left NAcc and bilateral inferior frontal gyri and the left postcentral gyrus (PG). Additionally, FHP youth differed from FHN youth in right NAcc functional connectivity with the left orbitofrontal cortex (OFC), left superior temporal gyrus, right cerebellum, left PG, and right occipital cortex. These results indicate that FHP youth have less segregation between the NAcc and executive functioning brain regions, and less integration with reward-related brain areas, such as the OFC. The findings of the current study highlight that premorbid atypical connectivity of appetitive systems, in the absence of heavy alcohol use, may be a risk marker in FHP adolescents.

Original languageEnglish (US)
Pages (from-to)210-219
Number of pages10
JournalPsychiatry Research - Neuroimaging
Volume221
Issue number3
DOIs
StatePublished - Mar 30 2014

Fingerprint

Nucleus Accumbens
Alcoholism
Prefrontal Cortex
Somatosensory Cortex
Alcohols
Reward
Brain
Occipital Lobe
Temporal Lobe
Cerebellum
Magnetic Resonance Imaging

Keywords

  • Adolescence
  • Alcohol
  • Familial
  • Risk
  • Ventral striatum

ASJC Scopus subject areas

  • Psychiatry and Mental health
  • Radiology Nuclear Medicine and imaging
  • Neuroscience (miscellaneous)

Cite this

Resting state functional connectivity of the nucleus accumbens in youth with a family history of alcoholism. / Cservenka, Anita; Casimo, Kaitlyn; Fair, Damien; Nagel, Bonnie.

In: Psychiatry Research - Neuroimaging, Vol. 221, No. 3, 30.03.2014, p. 210-219.

Research output: Contribution to journalArticle

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