Rest-activity cycle and melatonin rhythm in blind free-runners have similar periods

Jonathan Emens; Alfred J. Lewy; Amber L. Laurie; Jeannie B. Songer

doi:10.1177/0748730410379080

Rest-activity cycle and melatonin rhythm in blind free-runners have similar periods

Jonathan Emens, Alfred J. Lewy, Amber L. Laurie, Jeannie B. Songer

Research output: Contribution to journal › Article › peer-review

16 Scopus citations

Abstract

In the absence of the entraining light-dark cycle, most totally blind humans free-run, albeit with relative coordination to nonphotic zeitgebers. Such blind free-runners (BFRs) often attempt to maintain a 24-h sleep-wake schedule and consequently suffer from recurrent sleep disruption and daytime somnolence. This study was conducted to determine the periods of the free-running melatonin rhythm and of the rest-activity cycle in 16 BFRs. It was found that the non-24-h component of the rest-activity rhythm correlated with the observed period of the circadian pacemaker.

Original language	English (US)
Pages (from-to)	381-384
Number of pages	4
Journal	Journal of biological rhythms
Volume	25
Issue number	5
DOIs	https://doi.org/10.1177/0748730410379080
State	Published - Oct 2010

Keywords

blindness
circadian
entrainment
human
melatonin
relative coordination

ASJC Scopus subject areas

Physiology
Physiology (medical)

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10.1177/0748730410379080

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abstract = "In the absence of the entraining light-dark cycle, most totally blind humans free-run, albeit with relative coordination to nonphotic zeitgebers. Such blind free-runners (BFRs) often attempt to maintain a 24-h sleep-wake schedule and consequently suffer from recurrent sleep disruption and daytime somnolence. This study was conducted to determine the periods of the free-running melatonin rhythm and of the rest-activity cycle in 16 BFRs. It was found that the non-24-h component of the rest-activity rhythm correlated with the observed period of the circadian pacemaker.",

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AU - Lewy, Alfred J.

AU - Laurie, Amber L.

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AB - In the absence of the entraining light-dark cycle, most totally blind humans free-run, albeit with relative coordination to nonphotic zeitgebers. Such blind free-runners (BFRs) often attempt to maintain a 24-h sleep-wake schedule and consequently suffer from recurrent sleep disruption and daytime somnolence. This study was conducted to determine the periods of the free-running melatonin rhythm and of the rest-activity cycle in 16 BFRs. It was found that the non-24-h component of the rest-activity rhythm correlated with the observed period of the circadian pacemaker.

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KW - circadian

KW - entrainment

KW - human

KW - melatonin

KW - relative coordination

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ER -

Rest-activity cycle and melatonin rhythm in blind free-runners have similar periods

Abstract

Keywords

ASJC Scopus subject areas

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