Responses of areas 3b and 1 in anesthetized squirrel monkeys to single- and dual-site stimulation of the digits

Robert M. Friedman, Li Min Chen, Anna Roe

Research output: Contribution to journalArticle

43 Citations (Scopus)

Abstract

Stimulation of the skin evokes topographically organized activation in somatosensory cortex. This representation is context dependent, however, since a different cortical topography is observed in area 3b when stimulated with complex tactile stimuli that evoke the von Békésy funneling illusion. Here we report on the population responses, as observed with intrinsic optical imaging, of area 1 and area 3b in the anesthetized squirrel monkey to pressure indentation of distal finger pads. Individual finger pad stimulation revealed that area 1 exhibited a smaller magnification factor than 3b, as evidenced by a smaller area of activation elicited by distal finger pad stimulation. Effects of paired finger pad stimulation produced largely similar effects in area 1 and area 3b. Paired finger pad stimulation produced reductions in the area of digit activation in area 1, suggesting the presence of lateral inhibition and funneling of information in area 1. Suppressive effects were stronger for paired stimulations at adjacent than at nonadjacent sites. Single-unit recordings revealed a mixture of either a summation or a suppression of the response to paired finger stimulation, compared with single finger pad stimulation of the primary digit. However, the average population response showed that paired finger pad stimulation resulted in response suppression. Based on this study and previous studies, we suggest the presence of at least three distinct ranges of lateral inhibition in areas 3b and 1.

Original languageEnglish (US)
Pages (from-to)3185-3196
Number of pages12
JournalJournal of Neurophysiology
Volume100
Issue number6
DOIs
StatePublished - Dec 2008
Externally publishedYes

Fingerprint

Saimiri
Fingers
Somatosensory Cortex
Optical Imaging
Touch
Population
Pressure
Skin

ASJC Scopus subject areas

  • Physiology
  • Neuroscience(all)

Cite this

Responses of areas 3b and 1 in anesthetized squirrel monkeys to single- and dual-site stimulation of the digits. / Friedman, Robert M.; Chen, Li Min; Roe, Anna.

In: Journal of Neurophysiology, Vol. 100, No. 6, 12.2008, p. 3185-3196.

Research output: Contribution to journalArticle

@article{22a443579c15408a9cfaef1e52e5d98e,
title = "Responses of areas 3b and 1 in anesthetized squirrel monkeys to single- and dual-site stimulation of the digits",
abstract = "Stimulation of the skin evokes topographically organized activation in somatosensory cortex. This representation is context dependent, however, since a different cortical topography is observed in area 3b when stimulated with complex tactile stimuli that evoke the von B{\'e}k{\'e}sy funneling illusion. Here we report on the population responses, as observed with intrinsic optical imaging, of area 1 and area 3b in the anesthetized squirrel monkey to pressure indentation of distal finger pads. Individual finger pad stimulation revealed that area 1 exhibited a smaller magnification factor than 3b, as evidenced by a smaller area of activation elicited by distal finger pad stimulation. Effects of paired finger pad stimulation produced largely similar effects in area 1 and area 3b. Paired finger pad stimulation produced reductions in the area of digit activation in area 1, suggesting the presence of lateral inhibition and funneling of information in area 1. Suppressive effects were stronger for paired stimulations at adjacent than at nonadjacent sites. Single-unit recordings revealed a mixture of either a summation or a suppression of the response to paired finger stimulation, compared with single finger pad stimulation of the primary digit. However, the average population response showed that paired finger pad stimulation resulted in response suppression. Based on this study and previous studies, we suggest the presence of at least three distinct ranges of lateral inhibition in areas 3b and 1.",
author = "Friedman, {Robert M.} and Chen, {Li Min} and Anna Roe",
year = "2008",
month = "12",
doi = "10.1152/jn.90278.2008",
language = "English (US)",
volume = "100",
pages = "3185--3196",
journal = "Journal of Neurophysiology",
issn = "0022-3077",
publisher = "American Physiological Society",
number = "6",

}

TY - JOUR

T1 - Responses of areas 3b and 1 in anesthetized squirrel monkeys to single- and dual-site stimulation of the digits

AU - Friedman, Robert M.

AU - Chen, Li Min

AU - Roe, Anna

PY - 2008/12

Y1 - 2008/12

N2 - Stimulation of the skin evokes topographically organized activation in somatosensory cortex. This representation is context dependent, however, since a different cortical topography is observed in area 3b when stimulated with complex tactile stimuli that evoke the von Békésy funneling illusion. Here we report on the population responses, as observed with intrinsic optical imaging, of area 1 and area 3b in the anesthetized squirrel monkey to pressure indentation of distal finger pads. Individual finger pad stimulation revealed that area 1 exhibited a smaller magnification factor than 3b, as evidenced by a smaller area of activation elicited by distal finger pad stimulation. Effects of paired finger pad stimulation produced largely similar effects in area 1 and area 3b. Paired finger pad stimulation produced reductions in the area of digit activation in area 1, suggesting the presence of lateral inhibition and funneling of information in area 1. Suppressive effects were stronger for paired stimulations at adjacent than at nonadjacent sites. Single-unit recordings revealed a mixture of either a summation or a suppression of the response to paired finger stimulation, compared with single finger pad stimulation of the primary digit. However, the average population response showed that paired finger pad stimulation resulted in response suppression. Based on this study and previous studies, we suggest the presence of at least three distinct ranges of lateral inhibition in areas 3b and 1.

AB - Stimulation of the skin evokes topographically organized activation in somatosensory cortex. This representation is context dependent, however, since a different cortical topography is observed in area 3b when stimulated with complex tactile stimuli that evoke the von Békésy funneling illusion. Here we report on the population responses, as observed with intrinsic optical imaging, of area 1 and area 3b in the anesthetized squirrel monkey to pressure indentation of distal finger pads. Individual finger pad stimulation revealed that area 1 exhibited a smaller magnification factor than 3b, as evidenced by a smaller area of activation elicited by distal finger pad stimulation. Effects of paired finger pad stimulation produced largely similar effects in area 1 and area 3b. Paired finger pad stimulation produced reductions in the area of digit activation in area 1, suggesting the presence of lateral inhibition and funneling of information in area 1. Suppressive effects were stronger for paired stimulations at adjacent than at nonadjacent sites. Single-unit recordings revealed a mixture of either a summation or a suppression of the response to paired finger stimulation, compared with single finger pad stimulation of the primary digit. However, the average population response showed that paired finger pad stimulation resulted in response suppression. Based on this study and previous studies, we suggest the presence of at least three distinct ranges of lateral inhibition in areas 3b and 1.

UR - http://www.scopus.com/inward/record.url?scp=57449098037&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=57449098037&partnerID=8YFLogxK

U2 - 10.1152/jn.90278.2008

DO - 10.1152/jn.90278.2008

M3 - Article

C2 - 18922955

AN - SCOPUS:57449098037

VL - 100

SP - 3185

EP - 3196

JO - Journal of Neurophysiology

JF - Journal of Neurophysiology

SN - 0022-3077

IS - 6

ER -