Responses of amniotic fluid volume and its four major flows to lung liquid diversion and amniotic infusion in the ovine fetus

Patricia Robertson, J. Job Faber, Robert A. Brace, Samantha Louey, Alan (Roger) Hohimer, Lowell Davis, Debra Anderson

Research output: Contribution to journalArticle

22 Citations (Scopus)

Abstract

We designed experiments to allow direct measurement of amniotic fluid volume and continuous measurement of lung liquid production, swallowing, and urine production in fetal sheep. From these values, the rate of intramembranous absorption was calculated. Using this experimental design, the contribution of lung liquid to the control of amniotic fluid volume was examined. Fetuses were assigned to 1 of 4 protocols, each protocol lasting 3 days: control, isovolemic replacement of lung liquid, supplementation of amniotic fluid inflow by 4 L/day, and supplementation of amniotic inflow during isovolemic replacement of lung liquid. We found no effect of lung liquid replacement on any of the known flows into and out of the amniotic fluid. Although intramembranous absorption increased greatly during supplementation, the amniochorionic function curves were not altered by isovolemic lung liquid replacement. We conclude that lung liquid does not appear to contain a significant regulatory substance for amniotic fluid volume control.

Original languageEnglish (US)
Pages (from-to)88-93
Number of pages6
JournalReproductive Sciences
Volume16
Issue number1
DOIs
StatePublished - Jan 2009

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Amniotic Fluid
Sheep
Fetus
Lung
Lung Volume Measurements
Deglutition
Research Design
Urine

Keywords

  • Fetal lung liquid
  • Intramembranous absorption
  • Swallowing

ASJC Scopus subject areas

  • Obstetrics and Gynecology

Cite this

Responses of amniotic fluid volume and its four major flows to lung liquid diversion and amniotic infusion in the ovine fetus. / Robertson, Patricia; Faber, J. Job; Brace, Robert A.; Louey, Samantha; Hohimer, Alan (Roger); Davis, Lowell; Anderson, Debra.

In: Reproductive Sciences, Vol. 16, No. 1, 01.2009, p. 88-93.

Research output: Contribution to journalArticle

Robertson, Patricia ; Faber, J. Job ; Brace, Robert A. ; Louey, Samantha ; Hohimer, Alan (Roger) ; Davis, Lowell ; Anderson, Debra. / Responses of amniotic fluid volume and its four major flows to lung liquid diversion and amniotic infusion in the ovine fetus. In: Reproductive Sciences. 2009 ; Vol. 16, No. 1. pp. 88-93.
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