Response to selection for sensitivity to ethanol hypothermia: Genetic analyses

Tamara J. Phillips; Erik S. Terdal; John C. Crabbe

doi:10.1007/BF01067713

Response to selection for sensitivity to ethanol hypothermia: Genetic analyses

Tamara J. Phillips, Erik S. Terdal, John C. Crabbe

Behavioral Neuroscience

Research output: Contribution to journal › Article › peer-review

15 Scopus citations

Abstract

Selective breeding has been used to produce lines of mice differing in sensitivity to the hypothermic effects of ethanol (EtOH). Two genetically independent HOT (insensitive) and two COLD (sensitive) lines are maintained along with two nonselected control (CON) lines. The breeding program is currently in selected generation 14, and HOT and COLD mice differ by about 4°C in selected hypothermic response. Estimates of heritability indicate that approximately 20% of the variance in EtOH-induced hypothermic response in mice is of additive genetic origin. Inbreeding has increased at a rate of about 1.7% per generation and no fertility problems have been detected as a result of selection. Projects designed to evaluate apparent correlated responses to selection are discussed.

Original language	English (US)
Pages (from-to)	473-480
Number of pages	8
Journal	Behavior genetics
Volume	20
Issue number	4
DOIs	https://doi.org/10.1007/BF01067713
State	Published - Jul 1990

Keywords

COLD mice
HOT mice
ethanol
heritability
hypothermia
pharmacogenetics
selection

ASJC Scopus subject areas

Ecology, Evolution, Behavior and Systematics
Genetics
Genetics(clinical)

Access to Document

10.1007/BF01067713

Cite this

@article{4791532306dc4b99ae380754eb9d7cf7,

title = "Response to selection for sensitivity to ethanol hypothermia: Genetic analyses",

abstract = "Selective breeding has been used to produce lines of mice differing in sensitivity to the hypothermic effects of ethanol (EtOH). Two genetically independent HOT (insensitive) and two COLD (sensitive) lines are maintained along with two nonselected control (CON) lines. The breeding program is currently in selected generation 14, and HOT and COLD mice differ by about 4°C in selected hypothermic response. Estimates of heritability indicate that approximately 20% of the variance in EtOH-induced hypothermic response in mice is of additive genetic origin. Inbreeding has increased at a rate of about 1.7% per generation and no fertility problems have been detected as a result of selection. Projects designed to evaluate apparent correlated responses to selection are discussed.",

keywords = "COLD mice, HOT mice, ethanol, heritability, hypothermia, pharmacogenetics, selection",

author = "Phillips, {Tamara J.} and Terdal, {Erik S.} and Crabbe, {John C.}",

year = "1990",

month = jul,

doi = "10.1007/BF01067713",

language = "English (US)",

volume = "20",

pages = "473--480",

journal = "Behavior genetics",

issn = "0001-8244",

publisher = "Springer New York",

number = "4",

}

TY - JOUR

T1 - Response to selection for sensitivity to ethanol hypothermia

T2 - Genetic analyses

AU - Phillips, Tamara J.

AU - Terdal, Erik S.

AU - Crabbe, John C.

PY - 1990/7

Y1 - 1990/7

N2 - Selective breeding has been used to produce lines of mice differing in sensitivity to the hypothermic effects of ethanol (EtOH). Two genetically independent HOT (insensitive) and two COLD (sensitive) lines are maintained along with two nonselected control (CON) lines. The breeding program is currently in selected generation 14, and HOT and COLD mice differ by about 4°C in selected hypothermic response. Estimates of heritability indicate that approximately 20% of the variance in EtOH-induced hypothermic response in mice is of additive genetic origin. Inbreeding has increased at a rate of about 1.7% per generation and no fertility problems have been detected as a result of selection. Projects designed to evaluate apparent correlated responses to selection are discussed.

AB - Selective breeding has been used to produce lines of mice differing in sensitivity to the hypothermic effects of ethanol (EtOH). Two genetically independent HOT (insensitive) and two COLD (sensitive) lines are maintained along with two nonselected control (CON) lines. The breeding program is currently in selected generation 14, and HOT and COLD mice differ by about 4°C in selected hypothermic response. Estimates of heritability indicate that approximately 20% of the variance in EtOH-induced hypothermic response in mice is of additive genetic origin. Inbreeding has increased at a rate of about 1.7% per generation and no fertility problems have been detected as a result of selection. Projects designed to evaluate apparent correlated responses to selection are discussed.

KW - COLD mice

KW - HOT mice

KW - ethanol

KW - heritability

KW - hypothermia

KW - pharmacogenetics

KW - selection

UR - http://www.scopus.com/inward/record.url?scp=0024993865&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=0024993865&partnerID=8YFLogxK

U2 - 10.1007/BF01067713

DO - 10.1007/BF01067713

M3 - Article

C2 - 2256890

AN - SCOPUS:0024993865

SN - 0001-8244

VL - 20

SP - 473

EP - 480

JO - Behavior genetics

JF - Behavior genetics

IS - 4

ER -

Response to selection for sensitivity to ethanol hypothermia: Genetic analyses

Abstract

Keywords

ASJC Scopus subject areas

Access to Document

Other files and links

Fingerprint

Cite this