Response to diazepam in sons of alcoholics

D. S. Cowley, P. P. Roy-Byrne, C. Godon, D. J. Greenblatt, R. Ries, Roger (Dale) Walker, H. H. Samson, D. W. Hommer

Research output: Contribution to journalArticle

29 Citations (Scopus)

Abstract

Alcohol exerts several of its actions via the chloride channel associated with the central GABA-benzodiazepine receptor complex. To explore a possible role for this receptor complex in risk for alcoholism, and to determine whether risk for alcoholism is associated with risk for benzodiazepine abuse, the authors administered intravenous diazepam to 18 sons of male alcoholics (SOAs) and 18 control subjects. Four logarithmically increasing doses of diazepam and matched volumes of placebo were given in randomized order on separate days about 1 week apart. SOAs were significantly more likely than controls to report euphoric responses to diazepam. At some diazepam doses, SOAs were more likely to report feeling 'high' and 'intoxicated.' SOAs and controls did not differ in feeling 'drugged.' SOAs and controls may differ in expectations regarding the subjective effects of drugs and/or in the function of the central GABA-benzodiazepine receptor complex. These findings also add further evidence for increased pleasurable effects, and thus possibly increased risk for benzodiazepine abuse, in a subgroup of SOAs.

Original languageEnglish (US)
Pages (from-to)1057-1063
Number of pages7
JournalAlcoholism: Clinical and Experimental Research
Volume16
Issue number6
DOIs
StatePublished - 1992
Externally publishedYes

Fingerprint

Alcoholics
Diazepam
Nuclear Family
GABA-A Receptors
Benzodiazepines
Chloride Channels
Alcoholism
Emotions
Alcohols
Placebos
Pharmaceutical Preparations

Keywords

  • Alcoholism
  • Diazepam
  • Genetics
  • Subjective Effects

ASJC Scopus subject areas

  • Medicine (miscellaneous)
  • Toxicology

Cite this

Cowley, D. S., Roy-Byrne, P. P., Godon, C., Greenblatt, D. J., Ries, R., Walker, R. D., ... Hommer, D. W. (1992). Response to diazepam in sons of alcoholics. Alcoholism: Clinical and Experimental Research, 16(6), 1057-1063. https://doi.org/10.1111/j.1530-0277.1992.tb00699.x

Response to diazepam in sons of alcoholics. / Cowley, D. S.; Roy-Byrne, P. P.; Godon, C.; Greenblatt, D. J.; Ries, R.; Walker, Roger (Dale); Samson, H. H.; Hommer, D. W.

In: Alcoholism: Clinical and Experimental Research, Vol. 16, No. 6, 1992, p. 1057-1063.

Research output: Contribution to journalArticle

Cowley, DS, Roy-Byrne, PP, Godon, C, Greenblatt, DJ, Ries, R, Walker, RD, Samson, HH & Hommer, DW 1992, 'Response to diazepam in sons of alcoholics', Alcoholism: Clinical and Experimental Research, vol. 16, no. 6, pp. 1057-1063. https://doi.org/10.1111/j.1530-0277.1992.tb00699.x
Cowley, D. S. ; Roy-Byrne, P. P. ; Godon, C. ; Greenblatt, D. J. ; Ries, R. ; Walker, Roger (Dale) ; Samson, H. H. ; Hommer, D. W. / Response to diazepam in sons of alcoholics. In: Alcoholism: Clinical and Experimental Research. 1992 ; Vol. 16, No. 6. pp. 1057-1063.
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