Response of growth retarded patients with Hand Schuller Christian disease to growth hormone therapy

G. D. Braunstein, S. Raiti, J. W. Hansen, Peter Kohler

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Abstract

5 Patients with growth retardation due to Hand Schuller Christian disease were treated for a maximum of 2 yr with human growth hormone, which was administered intramuscularly, 3 times per wk, in doses of 2 IU. All patients experienced a significant increment in growth rate in comparison with the yr before the therapy. During the first yr of therapy, the mean growth rate was 7.5 cm, an increase of 5.2 cm over the pretreatment yr (p <0.01). The growth rate during the second yr of treatment was less, with a mean increase of 2.8 cm per yr (p <0.05). These results are similar to the response of patients with idiopathic growth hormone deficiency and add further evidence that the growth retardation associated with Hand Schuller Christian disease is due to an acquired growth hormone secretory deficiency.

Original languageEnglish (US)
Pages (from-to)332-333
Number of pages2
JournalNew England Journal of Medicine
Volume292
Issue number7
StatePublished - 1975
Externally publishedYes

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Langerhans Cell Histiocytosis
Growth Hormone
Growth
Therapeutics
Human Growth Hormone

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  • Medicine(all)

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Response of growth retarded patients with Hand Schuller Christian disease to growth hormone therapy. / Braunstein, G. D.; Raiti, S.; Hansen, J. W.; Kohler, Peter.

In: New England Journal of Medicine, Vol. 292, No. 7, 1975, p. 332-333.

Research output: Contribution to journalArticle

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