Respiratory symptoms, lung function, and mortality in a screening center cohort

William M. Vollmer, Lynn E. Mccamant, Larry R. Johnson, A (Sonia) Buist

Research output: Contribution to journalArticle

23 Citations (Scopus)

Abstract

Numerous studies have documented the effects of smoking and reduced pulmonary function on all-cause mortality. The effects of respiratory symptoms are less well studied. This paper examines the joint effects of respiratory symptoms, lung function, and smoking using 11-year mortality data on 698 subjects aged 25 years and older. Copies of death certificates were obtained for all 120 confirmed deaths, and cause of death was coded by a nosologist using the rules of the international Classification of Diseases, Ninth Revision. Symptoms of cough/phlegm, wheeze, and dyspnea were significantly associated with all-cause mortality in separate univanate analyses. On a cause-specific basis, these associations appeared to hold for chronic obstructive pulmonary disease, lung cancer, and vascular disease. Further analysis indicated that, for both smokers and nonsmokers, the presence of chronic cough and/or sputum production was related to mortality only in the presence of wheezing. In addition, among smokers, the presence of both cough/phlegm and wheeze was significantly associated with mortality only among subjects with low initial lung function. Although the limited number of deaths and the nonrandom nature of the cohort limit the generalizability of our findings, it seems clear, based on these results and other published studies, that symptoms of cough, phlegm, and/or wheeze have important adverse health implications even in the absence of smoking and reduced lung function. More studies using common methodological approaches are needed.

Original languageEnglish (US)
Pages (from-to)1157-1169
Number of pages13
JournalAmerican Journal of Epidemiology
Volume129
Issue number6
StatePublished - Jun 1989

Fingerprint

Cough
Lung
Mortality
Smoking
Death Certificates
Respiratory Sounds
International Classification of Diseases
Sputum
Vascular Diseases
Dyspnea
Chronic Obstructive Pulmonary Disease
Lung Diseases
Cause of Death
Lung Neoplasms
Health

Keywords

  • Mortality
  • Respiratory tract diseases
  • Smoking
  • Spirometry

ASJC Scopus subject areas

  • Geriatrics and Gerontology
  • Epidemiology

Cite this

Respiratory symptoms, lung function, and mortality in a screening center cohort. / Vollmer, William M.; Mccamant, Lynn E.; Johnson, Larry R.; Buist, A (Sonia).

In: American Journal of Epidemiology, Vol. 129, No. 6, 06.1989, p. 1157-1169.

Research output: Contribution to journalArticle

Vollmer, WM, Mccamant, LE, Johnson, LR & Buist, AS 1989, 'Respiratory symptoms, lung function, and mortality in a screening center cohort', American Journal of Epidemiology, vol. 129, no. 6, pp. 1157-1169.
Vollmer, William M. ; Mccamant, Lynn E. ; Johnson, Larry R. ; Buist, A (Sonia). / Respiratory symptoms, lung function, and mortality in a screening center cohort. In: American Journal of Epidemiology. 1989 ; Vol. 129, No. 6. pp. 1157-1169.
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