TY - JOUR
T1 - Respiratory sensations during heavy exercise in subjects without respiratory chemosensitivity
AU - Spengler, Christina M.
AU - Banzett, Robert B.
AU - Systrom, David M.
AU - Shannon, Daniel C.
AU - Shea, Steven A.
N1 - Funding Information:
We are very thankful to all the subjects and their parents who dedicated many hours to this study. We also thank the team of pulmonary physicians at Massachusetts General Hospital for clinical assistance during the exercise tests, Paul Pappagianopoulos, Cynthia Esteban and Susie Mahan for technical assistance, and Nicole Minotti who transcribed taped conversations with the subjects. This research was supported by NIH 46690. Christina M. Spengler was kindly supported by a Swiss National Science Foundation Fellowship.
PY - 1998/10
Y1 - 1998/10
N2 - Breathlessness arises from increased medullary respiratory center activity projecting to the forebrain (respiratory corollary discharge hypothesis). Subjects with congenital central hypoventilation syndrome (CCHS) lack the normal hyperpnea and breathlessness during hypercapnia. The corollary discharge hypothesis predicts that if CCHS subjects have normal hyperpnea during exercise, they will experience normal breathlessness during exercise. To test this, we studied four CCHS subjects and six matched controls during an exhausting constant-load cycling test requiring substantial anaerobiosis. CCHS subjects rated significantly less breathlessness at the end of the test than controls, but ventilation (index of respiratory corollary discharge) was also somewhat lower in CCHS (not significant). In both groups, breathlessness increased disproportionately more than ventilation towards the end of exercise. These data failed to disprove the corollary discharge hypothesis of breathlessness, but do suggest that the relationship between ventilation and breathlessness is non-linear and/or that projections of chemoreceptor afferents to the forebrain (presumed lacking in CCHS) is one source of breathlessness in normals. Copyright (C) 1998 Elsevier Science B.V.
AB - Breathlessness arises from increased medullary respiratory center activity projecting to the forebrain (respiratory corollary discharge hypothesis). Subjects with congenital central hypoventilation syndrome (CCHS) lack the normal hyperpnea and breathlessness during hypercapnia. The corollary discharge hypothesis predicts that if CCHS subjects have normal hyperpnea during exercise, they will experience normal breathlessness during exercise. To test this, we studied four CCHS subjects and six matched controls during an exhausting constant-load cycling test requiring substantial anaerobiosis. CCHS subjects rated significantly less breathlessness at the end of the test than controls, but ventilation (index of respiratory corollary discharge) was also somewhat lower in CCHS (not significant). In both groups, breathlessness increased disproportionately more than ventilation towards the end of exercise. These data failed to disprove the corollary discharge hypothesis of breathlessness, but do suggest that the relationship between ventilation and breathlessness is non-linear and/or that projections of chemoreceptor afferents to the forebrain (presumed lacking in CCHS) is one source of breathlessness in normals. Copyright (C) 1998 Elsevier Science B.V.
KW - Chemosensitivity, hypercapnic response
KW - Control of breathing, breathlessness
KW - Disease, congenital central hypoventilation syndrome
KW - Hypercapnia, breathlessness
KW - Mammals, humans, infants
KW - Sensation, breathlessness
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U2 - 10.1016/S0034-5687(98)00073-5
DO - 10.1016/S0034-5687(98)00073-5
M3 - Article
C2 - 9858052
AN - SCOPUS:0031731936
SN - 0034-5687
VL - 114
SP - 65
EP - 74
JO - Respiration Physiology
JF - Respiration Physiology
IS - 1
ER -