Respiratory disorders related to smoking tobacco

John F. Murray, A (Sonia) Buist

Research output: Contribution to journalArticle

2 Citations (Scopus)

Abstract

Respiratory disorders are among the most frequent causes of death and severe disability from the steadily worsening global pandemic of smoking tobacco. Two disorders stand out: lung cancer and chronic obstructive pulmonary disease (COPD). First, lung cancer caused 1.59 million deaths worldwide in 2012, more than the next two top cancer causes combined (liver and stomach). Tobacco smoke induces pathologic changes in the bronchial epithelium that often progress to fatal invasive lung cancer. For the first time, the recent US National Lung Screening Trial reported a significant (20%) reduction in lung cancer mortality in current or previous heavy smokers detected by low-dose, spiral computed tomography. Second, dramatic advances in understanding COPD include the recognition that it is a complex, multisystem disease that involves many organs-not just the lungs. COPD results from an inflammatory process leading to narrowing and scarring of small airways and destruction of lung parenchyma causing emphysema. Tobacco smoke remains the most important risk factor for COPD globally, but occupational and environmental exposures play increasing roles. Tobacco smoke is also the principal cause of certain interstitial lung diseases and worsens others. Both prenatal and postnatal tobacco exposure contribute to impairment in lung growth and development, and increase the risk of acquiring infectious pneumonias and tuberculosis.

Original languageEnglish (US)
Pages (from-to)72-84
Number of pages13
JournalProgress in Respiratory Research
Volume42
DOIs
StatePublished - 2015

Fingerprint

Chronic Obstructive Pulmonary Disease
Tobacco
Lung Neoplasms
Smoking
Smoke
Lung
Spiral Computed Tomography
Interstitial Lung Diseases
Environmental Exposure
Emphysema
Pandemics
Occupational Exposure
Growth and Development
Cicatrix
Cause of Death
Pneumonia
Stomach
Tuberculosis
Epithelium
Mortality

ASJC Scopus subject areas

  • Pulmonary and Respiratory Medicine

Cite this

Respiratory disorders related to smoking tobacco. / Murray, John F.; Buist, A (Sonia).

In: Progress in Respiratory Research, Vol. 42, 2015, p. 72-84.

Research output: Contribution to journalArticle

@article{d9dde7f05856452cb9459e33d8789ebb,
title = "Respiratory disorders related to smoking tobacco",
abstract = "Respiratory disorders are among the most frequent causes of death and severe disability from the steadily worsening global pandemic of smoking tobacco. Two disorders stand out: lung cancer and chronic obstructive pulmonary disease (COPD). First, lung cancer caused 1.59 million deaths worldwide in 2012, more than the next two top cancer causes combined (liver and stomach). Tobacco smoke induces pathologic changes in the bronchial epithelium that often progress to fatal invasive lung cancer. For the first time, the recent US National Lung Screening Trial reported a significant (20{\%}) reduction in lung cancer mortality in current or previous heavy smokers detected by low-dose, spiral computed tomography. Second, dramatic advances in understanding COPD include the recognition that it is a complex, multisystem disease that involves many organs-not just the lungs. COPD results from an inflammatory process leading to narrowing and scarring of small airways and destruction of lung parenchyma causing emphysema. Tobacco smoke remains the most important risk factor for COPD globally, but occupational and environmental exposures play increasing roles. Tobacco smoke is also the principal cause of certain interstitial lung diseases and worsens others. Both prenatal and postnatal tobacco exposure contribute to impairment in lung growth and development, and increase the risk of acquiring infectious pneumonias and tuberculosis.",
author = "Murray, {John F.} and Buist, {A (Sonia)}",
year = "2015",
doi = "10.1159/000369327",
language = "English (US)",
volume = "42",
pages = "72--84",
journal = "Progress in Respiratory Research",
issn = "1422-2140",
publisher = "S. Karger AG",

}

TY - JOUR

T1 - Respiratory disorders related to smoking tobacco

AU - Murray, John F.

AU - Buist, A (Sonia)

PY - 2015

Y1 - 2015

N2 - Respiratory disorders are among the most frequent causes of death and severe disability from the steadily worsening global pandemic of smoking tobacco. Two disorders stand out: lung cancer and chronic obstructive pulmonary disease (COPD). First, lung cancer caused 1.59 million deaths worldwide in 2012, more than the next two top cancer causes combined (liver and stomach). Tobacco smoke induces pathologic changes in the bronchial epithelium that often progress to fatal invasive lung cancer. For the first time, the recent US National Lung Screening Trial reported a significant (20%) reduction in lung cancer mortality in current or previous heavy smokers detected by low-dose, spiral computed tomography. Second, dramatic advances in understanding COPD include the recognition that it is a complex, multisystem disease that involves many organs-not just the lungs. COPD results from an inflammatory process leading to narrowing and scarring of small airways and destruction of lung parenchyma causing emphysema. Tobacco smoke remains the most important risk factor for COPD globally, but occupational and environmental exposures play increasing roles. Tobacco smoke is also the principal cause of certain interstitial lung diseases and worsens others. Both prenatal and postnatal tobacco exposure contribute to impairment in lung growth and development, and increase the risk of acquiring infectious pneumonias and tuberculosis.

AB - Respiratory disorders are among the most frequent causes of death and severe disability from the steadily worsening global pandemic of smoking tobacco. Two disorders stand out: lung cancer and chronic obstructive pulmonary disease (COPD). First, lung cancer caused 1.59 million deaths worldwide in 2012, more than the next two top cancer causes combined (liver and stomach). Tobacco smoke induces pathologic changes in the bronchial epithelium that often progress to fatal invasive lung cancer. For the first time, the recent US National Lung Screening Trial reported a significant (20%) reduction in lung cancer mortality in current or previous heavy smokers detected by low-dose, spiral computed tomography. Second, dramatic advances in understanding COPD include the recognition that it is a complex, multisystem disease that involves many organs-not just the lungs. COPD results from an inflammatory process leading to narrowing and scarring of small airways and destruction of lung parenchyma causing emphysema. Tobacco smoke remains the most important risk factor for COPD globally, but occupational and environmental exposures play increasing roles. Tobacco smoke is also the principal cause of certain interstitial lung diseases and worsens others. Both prenatal and postnatal tobacco exposure contribute to impairment in lung growth and development, and increase the risk of acquiring infectious pneumonias and tuberculosis.

UR - http://www.scopus.com/inward/record.url?scp=84926299423&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=84926299423&partnerID=8YFLogxK

U2 - 10.1159/000369327

DO - 10.1159/000369327

M3 - Article

VL - 42

SP - 72

EP - 84

JO - Progress in Respiratory Research

JF - Progress in Respiratory Research

SN - 1422-2140

ER -