Respiratory cryptosporidiosis in a patient with malignant lymphoma. Report of a case and review of the literature

W. D. Travis, K. Schmidt, James Maclowry, H. Masur, K. S. Condron, A. T. Fojo

Research output: Contribution to journalArticle

32 Citations (Scopus)

Abstract

Respiratory cryptosporidiosis is a rare complication of intestinal infection by cryptosporidia, with only six cases reported (to our knowledge) since its first description in 1983. We report the first case of respiratory cryptosporidiosis recognized at the National Institutes of Health, Bethesda, Md. An antemortem diagnosis was made based on recognition of acid-fast cryptosporidia in an induced sputum specimen obtained from a 64-year-old woman with malignant lymphoma and an associated profound immunodeficiency. Autopsy confirmed the presence of cryptosporidia along the apical aspect of the respiratory epithelium lining the trachea, bronchi, and bronchioles. Cryptosporidia were also identified in the duodenum and gallbladder. Immunohistochemical staining of the paraffin-embedded autopsy lung sections using a monoclonal antibody verified the diagnosis of cryptosporidiosis. Review of our case and the literature suggests that respiratory cryptosporidiosis is characterized by a chronic tracheitis, bronchitis, and bronchiolitis but generally does not cause severe pulmonary dysfunction.

Original languageEnglish (US)
Pages (from-to)519-522
Number of pages4
JournalArchives of Pathology and Laboratory Medicine
Volume114
Issue number5
StatePublished - 1990
Externally publishedYes

Fingerprint

Cryptosporidiosis
Cryptosporidium
Lymphoma
Autopsy
Tracheitis
Bronchioles
Respiratory Mucosa
Lung
Bronchiolitis
Chronic Bronchitis
National Institutes of Health (U.S.)
Bronchi
Trachea
Gallbladder
Sputum
Duodenum
Paraffin
Monoclonal Antibodies
Staining and Labeling
Acids

ASJC Scopus subject areas

  • Pathology and Forensic Medicine
  • Medical Laboratory Technology

Cite this

Respiratory cryptosporidiosis in a patient with malignant lymphoma. Report of a case and review of the literature. / Travis, W. D.; Schmidt, K.; Maclowry, James; Masur, H.; Condron, K. S.; Fojo, A. T.

In: Archives of Pathology and Laboratory Medicine, Vol. 114, No. 5, 1990, p. 519-522.

Research output: Contribution to journalArticle

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