Respiratory complications associated with ketamine anesthesia for ophthalmic procedures following intraocular pressure measurement in children

Lei Wu, Kirk Lalwani, Karla A. Hook, Bella M. Almario, Rongwei (Rochelle) Fu, Lorna (Beth) Edmunds

Research output: Contribution to journalArticle

1 Citation (Scopus)

Abstract

Background: We compared respiratory complications (RCs) in children who received intramuscular (IM) versus intravenous (IV) or no ketamine for intraocular pressure (IOP) measurement to test our observation that IM ketamine is associated with higher incidence of RCs. Materials and Methods: We analyzed 149 eye examinations under anesthesia with ketamine in 27 patients and 263 non-ketamine examinations under anesthesia in 81 patients using a mixed effects logistic regression model. Results: IM ketamine was strongly associated with increased odds of RCs compared to no ketamine (odds ratio (OR): 20.23, P <0.0001) and to IV ketamine (OR: 6.78, P = 0.02), as were higher American Society of Anesthesiologists (ASA) classification (OR: 2.60, P = 0.04), and the use of volatile agents (OR: 3.32, P = 0.02). Conclusion: Further studies should be conducted to confirm our observation of increased RCs with IM ketamine.

Original languageEnglish (US)
Pages (from-to)253-257
Number of pages5
JournalJournal of Anaesthesiology Clinical Pharmacology
Volume30
Issue number2
DOIs
StatePublished - 2014

Fingerprint

Ketamine
Intraocular Pressure
Anesthesia
Odds Ratio
Logistic Models
Observation
Incidence

Keywords

  • Adverse events
  • child
  • infant
  • intravenous agents
  • ophthalmology

ASJC Scopus subject areas

  • Pharmacology (medical)
  • Anesthesiology and Pain Medicine
  • Pharmacology, Toxicology and Pharmaceutics(all)

Cite this

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title = "Respiratory complications associated with ketamine anesthesia for ophthalmic procedures following intraocular pressure measurement in children",
abstract = "Background: We compared respiratory complications (RCs) in children who received intramuscular (IM) versus intravenous (IV) or no ketamine for intraocular pressure (IOP) measurement to test our observation that IM ketamine is associated with higher incidence of RCs. Materials and Methods: We analyzed 149 eye examinations under anesthesia with ketamine in 27 patients and 263 non-ketamine examinations under anesthesia in 81 patients using a mixed effects logistic regression model. Results: IM ketamine was strongly associated with increased odds of RCs compared to no ketamine (odds ratio (OR): 20.23, P <0.0001) and to IV ketamine (OR: 6.78, P = 0.02), as were higher American Society of Anesthesiologists (ASA) classification (OR: 2.60, P = 0.04), and the use of volatile agents (OR: 3.32, P = 0.02). Conclusion: Further studies should be conducted to confirm our observation of increased RCs with IM ketamine.",
keywords = "Adverse events, child, infant, intravenous agents, ophthalmology",
author = "Lei Wu and Kirk Lalwani and Hook, {Karla A.} and Almario, {Bella M.} and Fu, {Rongwei (Rochelle)} and Edmunds, {Lorna (Beth)}",
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language = "English (US)",
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T1 - Respiratory complications associated with ketamine anesthesia for ophthalmic procedures following intraocular pressure measurement in children

AU - Wu, Lei

AU - Lalwani, Kirk

AU - Hook, Karla A.

AU - Almario, Bella M.

AU - Fu, Rongwei (Rochelle)

AU - Edmunds, Lorna (Beth)

PY - 2014

Y1 - 2014

N2 - Background: We compared respiratory complications (RCs) in children who received intramuscular (IM) versus intravenous (IV) or no ketamine for intraocular pressure (IOP) measurement to test our observation that IM ketamine is associated with higher incidence of RCs. Materials and Methods: We analyzed 149 eye examinations under anesthesia with ketamine in 27 patients and 263 non-ketamine examinations under anesthesia in 81 patients using a mixed effects logistic regression model. Results: IM ketamine was strongly associated with increased odds of RCs compared to no ketamine (odds ratio (OR): 20.23, P <0.0001) and to IV ketamine (OR: 6.78, P = 0.02), as were higher American Society of Anesthesiologists (ASA) classification (OR: 2.60, P = 0.04), and the use of volatile agents (OR: 3.32, P = 0.02). Conclusion: Further studies should be conducted to confirm our observation of increased RCs with IM ketamine.

AB - Background: We compared respiratory complications (RCs) in children who received intramuscular (IM) versus intravenous (IV) or no ketamine for intraocular pressure (IOP) measurement to test our observation that IM ketamine is associated with higher incidence of RCs. Materials and Methods: We analyzed 149 eye examinations under anesthesia with ketamine in 27 patients and 263 non-ketamine examinations under anesthesia in 81 patients using a mixed effects logistic regression model. Results: IM ketamine was strongly associated with increased odds of RCs compared to no ketamine (odds ratio (OR): 20.23, P <0.0001) and to IV ketamine (OR: 6.78, P = 0.02), as were higher American Society of Anesthesiologists (ASA) classification (OR: 2.60, P = 0.04), and the use of volatile agents (OR: 3.32, P = 0.02). Conclusion: Further studies should be conducted to confirm our observation of increased RCs with IM ketamine.

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KW - infant

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