Resistance to multiple steroids in two sisters

Maria I. New, S. Nimkarn, D. D. Brandon, S. Cunningham-Rundles, R. C. Wilson, R. S. Newfield, J. Vandermeulen, N. Barron, C. Russo, Donald (Lynn) Loriaux, B. O'Malley

Research output: Contribution to journalArticle

12 Citations (Scopus)

Abstract

A 14-year-old Native American girl from the Iroquois Nation was referred as a potential patient with the syndrome of Apparent Mineralocorticoid Excess. Instead, her evaluation revealed resistance to glucocorticoids, mineralocorticoids, and androgens. She lacked Cushingoid features in spite of significantly high cortisol levels. Menstruation was regular and there was no clinical evidence of masculinization despite high serum androgen levels in the male range. The patient's sister had similar clinical features. Partial resistance to exogenous glucocorticoid and mineralocorticoid administration was well demonstrated in both patients. It is proposed that these patients represent the first cases of partial resistance to multiple steroids, possibly owing to a coactivator defect.

Original languageEnglish (US)
Pages (from-to)161-166
Number of pages6
JournalJournal of Steroid Biochemistry and Molecular Biology
Volume76
Issue number1-5
DOIs
StatePublished - 2001

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Mineralocorticoids
Siblings
Steroids
Glucocorticoids
Androgens
Apparent Mineralocorticoid Excess Syndrome
Menstruation
North American Indians
Hydrocortisone
Defects
Serum

ASJC Scopus subject areas

  • Biochemistry
  • Endocrinology

Cite this

New, M. I., Nimkarn, S., Brandon, D. D., Cunningham-Rundles, S., Wilson, R. C., Newfield, R. S., ... O'Malley, B. (2001). Resistance to multiple steroids in two sisters. Journal of Steroid Biochemistry and Molecular Biology, 76(1-5), 161-166. https://doi.org/10.1016/S0960-0760(01)00045-0

Resistance to multiple steroids in two sisters. / New, Maria I.; Nimkarn, S.; Brandon, D. D.; Cunningham-Rundles, S.; Wilson, R. C.; Newfield, R. S.; Vandermeulen, J.; Barron, N.; Russo, C.; Loriaux, Donald (Lynn); O'Malley, B.

In: Journal of Steroid Biochemistry and Molecular Biology, Vol. 76, No. 1-5, 2001, p. 161-166.

Research output: Contribution to journalArticle

New, MI, Nimkarn, S, Brandon, DD, Cunningham-Rundles, S, Wilson, RC, Newfield, RS, Vandermeulen, J, Barron, N, Russo, C, Loriaux, DL & O'Malley, B 2001, 'Resistance to multiple steroids in two sisters', Journal of Steroid Biochemistry and Molecular Biology, vol. 76, no. 1-5, pp. 161-166. https://doi.org/10.1016/S0960-0760(01)00045-0
New MI, Nimkarn S, Brandon DD, Cunningham-Rundles S, Wilson RC, Newfield RS et al. Resistance to multiple steroids in two sisters. Journal of Steroid Biochemistry and Molecular Biology. 2001;76(1-5):161-166. https://doi.org/10.1016/S0960-0760(01)00045-0
New, Maria I. ; Nimkarn, S. ; Brandon, D. D. ; Cunningham-Rundles, S. ; Wilson, R. C. ; Newfield, R. S. ; Vandermeulen, J. ; Barron, N. ; Russo, C. ; Loriaux, Donald (Lynn) ; O'Malley, B. / Resistance to multiple steroids in two sisters. In: Journal of Steroid Biochemistry and Molecular Biology. 2001 ; Vol. 76, No. 1-5. pp. 161-166.
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