Residual cardiovascular risk despite optimal LDL cholesterol reduction with statins: The evidence, etiology, and therapeutic challenges

Uchechukwu K. Sampson, Sergio Fazio, MacRae F. Linton

    Research output: Contribution to journalArticlepeer-review

    166 Scopus citations

    Abstract

    This review captures the existence, cause, and treatment challenges of residual cardiovascular risk (CVR) after aggressive low-density lipoprotein cholesterol (LDL-C) reduction. Scientific evidence implicates low high-density lipoprotein cholesterol (HDL-C) and high triglycerides (TG) in the CVR observed after LDL-C lowering. However, the Action to Control Cardiovascular Risk in Diabetes (ACCORD) lipid trial with fenofibrate, the Investigation of Lipid Level Management to Understand its Impact in Atherosclerotic Events (ILLUMINATE) study with torcetrapib, and the recently terminated Atherothrombosis Intervention in Metabolic Syndrome with Low HDL Cholesterol/High Triglyceride and Impact on Global Health Outcomes (AIM-HIGH) study with niacin, do not clearly attribute risk reduction value to HDL-C/TG modulation. The optimum approach to long-term lipid-modifying therapies for CVR reduction remains uncertain. Consequently, absolute risk modulation via lifestyle changes remains the centerpiece of a strategy addressing the physiologic drivers of CVR associated with HDL-C/TG, especially in the context of diabetes/metabolic syndrome.

    Original languageEnglish (US)
    Pages (from-to)1-10
    Number of pages10
    JournalCurrent atherosclerosis reports
    Volume14
    Issue number1
    DOIs
    StatePublished - Feb 2012

    Keywords

    • CV risk reduction
    • LDL cholesterol
    • Residual CV risk
    • Statins

    ASJC Scopus subject areas

    • Cardiology and Cardiovascular Medicine

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