Abstract
A large population of perivascular cells was found to be present in the area of the blood-labyrinth barrier in the stria vascularis of normal adult cochlea. The cells were identified as perivascular resident macrophages (PVMs), as they were positive for several macrophage surface molecules including F4/80, CD68, and CD11b. The macrophages, which were closely associated with microvessels and structurally intertwined with endothelial cells and pericytes, constitutively expressed scavenger receptor classes A1 and B 1 and accumulated blood-borne proteins such as horseradish peroxidase and acetylated low-density lipoprotein. The PVMs were demonstrated to proliferate slowly, as evidenced by the absence of 5-bromo-2-deoxyuridine (BrdU)-positive PVMs at 3-14 days in normal mice injected with BrdU. However, in irradiated mice, the majority of the PVMs turned over via bone-marrow-cell migration within a 10-month time-frame. The existence of PVMs in the vascular wall of the blood-labyrinth barrier might therefore serve as a source for progenitor cells for postnatal vasculogenesis and might contribute to the repair of damaged vessels in the context of a local inflammatory response.
Original language | English (US) |
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Pages (from-to) | 21-30 |
Number of pages | 10 |
Journal | Cell and tissue research |
Volume | 342 |
Issue number | 1 |
DOIs | |
State | Published - Oct 1 2010 |
Keywords
- Cochlea
- Confocal laser microscopy
- Immunohistochemistry
- Mouse (C57BL/6J; C57Bl/6-Tg)
- Resident macrophage
ASJC Scopus subject areas
- Pathology and Forensic Medicine
- Histology
- Cell Biology