Researcher and institutional review board chair perspectives on incidental findings in genomic research

Janet K. Williams, Sandra Daack-Hirsch, Martha Driessnack, Nancy Downing, Laura Shinkunas, Debra Brandt, Christian Simon

Research output: Contribution to journalArticle

21 Scopus citations

Abstract

Aims: Genomic research can produce findings unrelated to a study's aims. The purpose of this study was to examine researcher and Institutional Review Board (IRB) chair perspectives on genomic incidental findings (GIFs). Methods: Nineteen genomic researchers and 34 IRB chairs from 42 institutions participated in semi-structured telephone interviews. Researchers and chairs described GIFs within their respective roles. Few had direct experience with disclosure of GIFs. Researchers favored policies where a case by case determination regarding whether GIF disclosure would be offered after discovery, whereas IRB chairs preferred policies where procedures for disclosure would be determined prior to approval of the research. Conclusions: Researcher and IRB chair perspectives on management of GIFs overlap, but each group provides a unique perspective on decisions regarding disclosure of GIFs in research. Engagement of both groups is essential in efforts to provide guidance for researchers and IRBs regarding disclosure of GIFs in research.

Original languageEnglish (US)
Pages (from-to)508-513
Number of pages6
JournalGenetic Testing and Molecular Biomarkers
Volume16
Issue number6
DOIs
StatePublished - Jun 1 2012

ASJC Scopus subject areas

  • Genetics(clinical)

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