Research Review

Functional brain connectivity and child psychopathology - Overview and methodological considerations for investigators new to the field

Marguerite Matthews, Damien Fair

Research output: Contribution to journalArticle

11 Citations (Scopus)

Abstract

Background Functional connectivity MRI is an emerging technique that can be used to investigate typical and atypical brain function in developing and aging populations. Despite some of the current confounds in the field of functional connectivity MRI, the translational potential of the technique available to investigators may eventually be used to improve diagnosis, early disease detection, and therapy monitoring. Method and Scope Based on a comprehensive survey of the literature, this review offers an introduction of resting-state functional connectivity for new investigators to the field of resting-state functional connectivity. We discuss a brief history of the technique, various methods of analysis, the relationship of functional networks to behavior, as well as the translational potential of functional connectivity MRI to investigate neuropsychiatric disorders. We also address some considerations and limitations with data analysis and interpretation. Conclusions The information provided in this review should serve as a foundation for investigators new to the field of resting-state functional connectivity. The discussion provides a means to better understand functional connectivity and its application to typical and atypical brain function.

Original languageEnglish (US)
Pages (from-to)400-414
Number of pages15
JournalJournal of Child Psychology and Psychiatry and Allied Disciplines
Volume56
Issue number4
DOIs
StatePublished - Apr 1 2015

Fingerprint

Psychopathology
Research Personnel
Magnetic Resonance Imaging
Brain
Research
Secondary Prevention
Population

Keywords

  • child psychopathology
  • fMRI
  • functional connectivity
  • machine learning
  • neuropsychiatric disorders
  • resting-state networks

ASJC Scopus subject areas

  • Psychiatry and Mental health
  • Pediatrics, Perinatology, and Child Health
  • Developmental and Educational Psychology

Cite this

@article{eb2b3ee4d46f404089cc40d84f5b96e4,
title = "Research Review: Functional brain connectivity and child psychopathology - Overview and methodological considerations for investigators new to the field",
abstract = "Background Functional connectivity MRI is an emerging technique that can be used to investigate typical and atypical brain function in developing and aging populations. Despite some of the current confounds in the field of functional connectivity MRI, the translational potential of the technique available to investigators may eventually be used to improve diagnosis, early disease detection, and therapy monitoring. Method and Scope Based on a comprehensive survey of the literature, this review offers an introduction of resting-state functional connectivity for new investigators to the field of resting-state functional connectivity. We discuss a brief history of the technique, various methods of analysis, the relationship of functional networks to behavior, as well as the translational potential of functional connectivity MRI to investigate neuropsychiatric disorders. We also address some considerations and limitations with data analysis and interpretation. Conclusions The information provided in this review should serve as a foundation for investigators new to the field of resting-state functional connectivity. The discussion provides a means to better understand functional connectivity and its application to typical and atypical brain function.",
keywords = "child psychopathology, fMRI, functional connectivity, machine learning, neuropsychiatric disorders, resting-state networks",
author = "Marguerite Matthews and Damien Fair",
year = "2015",
month = "4",
day = "1",
doi = "10.1111/jcpp.12335",
language = "English (US)",
volume = "56",
pages = "400--414",
journal = "Journal of Child Psychology and Psychiatry and Allied Disciplines",
issn = "0021-9630",
publisher = "Wiley-Blackwell",
number = "4",

}

TY - JOUR

T1 - Research Review

T2 - Functional brain connectivity and child psychopathology - Overview and methodological considerations for investigators new to the field

AU - Matthews, Marguerite

AU - Fair, Damien

PY - 2015/4/1

Y1 - 2015/4/1

N2 - Background Functional connectivity MRI is an emerging technique that can be used to investigate typical and atypical brain function in developing and aging populations. Despite some of the current confounds in the field of functional connectivity MRI, the translational potential of the technique available to investigators may eventually be used to improve diagnosis, early disease detection, and therapy monitoring. Method and Scope Based on a comprehensive survey of the literature, this review offers an introduction of resting-state functional connectivity for new investigators to the field of resting-state functional connectivity. We discuss a brief history of the technique, various methods of analysis, the relationship of functional networks to behavior, as well as the translational potential of functional connectivity MRI to investigate neuropsychiatric disorders. We also address some considerations and limitations with data analysis and interpretation. Conclusions The information provided in this review should serve as a foundation for investigators new to the field of resting-state functional connectivity. The discussion provides a means to better understand functional connectivity and its application to typical and atypical brain function.

AB - Background Functional connectivity MRI is an emerging technique that can be used to investigate typical and atypical brain function in developing and aging populations. Despite some of the current confounds in the field of functional connectivity MRI, the translational potential of the technique available to investigators may eventually be used to improve diagnosis, early disease detection, and therapy monitoring. Method and Scope Based on a comprehensive survey of the literature, this review offers an introduction of resting-state functional connectivity for new investigators to the field of resting-state functional connectivity. We discuss a brief history of the technique, various methods of analysis, the relationship of functional networks to behavior, as well as the translational potential of functional connectivity MRI to investigate neuropsychiatric disorders. We also address some considerations and limitations with data analysis and interpretation. Conclusions The information provided in this review should serve as a foundation for investigators new to the field of resting-state functional connectivity. The discussion provides a means to better understand functional connectivity and its application to typical and atypical brain function.

KW - child psychopathology

KW - fMRI

KW - functional connectivity

KW - machine learning

KW - neuropsychiatric disorders

KW - resting-state networks

UR - http://www.scopus.com/inward/record.url?scp=84924801615&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=84924801615&partnerID=8YFLogxK

U2 - 10.1111/jcpp.12335

DO - 10.1111/jcpp.12335

M3 - Article

VL - 56

SP - 400

EP - 414

JO - Journal of Child Psychology and Psychiatry and Allied Disciplines

JF - Journal of Child Psychology and Psychiatry and Allied Disciplines

SN - 0021-9630

IS - 4

ER -