Abstract
Background Functional connectivity MRI is an emerging technique that can be used to investigate typical and atypical brain function in developing and aging populations. Despite some of the current confounds in the field of functional connectivity MRI, the translational potential of the technique available to investigators may eventually be used to improve diagnosis, early disease detection, and therapy monitoring. Method and Scope Based on a comprehensive survey of the literature, this review offers an introduction of resting-state functional connectivity for new investigators to the field of resting-state functional connectivity. We discuss a brief history of the technique, various methods of analysis, the relationship of functional networks to behavior, as well as the translational potential of functional connectivity MRI to investigate neuropsychiatric disorders. We also address some considerations and limitations with data analysis and interpretation. Conclusions The information provided in this review should serve as a foundation for investigators new to the field of resting-state functional connectivity. The discussion provides a means to better understand functional connectivity and its application to typical and atypical brain function.
| Original language | English (US) |
|---|---|
| Pages (from-to) | 400-414 |
| Number of pages | 15 |
| Journal | Journal of Child Psychology and Psychiatry and Allied Disciplines |
| Volume | 56 |
| Issue number | 4 |
| DOIs | |
| State | Published - Apr 1 2015 |
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Keywords
- child psychopathology
- fMRI
- functional connectivity
- machine learning
- neuropsychiatric disorders
- resting-state networks
ASJC Scopus subject areas
- Psychiatry and Mental health
- Pediatrics, Perinatology, and Child Health
- Developmental and Educational Psychology
Cite this
Research Review : Functional brain connectivity and child psychopathology - Overview and methodological considerations for investigators new to the field. / Matthews, Marguerite; Fair, Damien.
In: Journal of Child Psychology and Psychiatry and Allied Disciplines, Vol. 56, No. 4, 01.04.2015, p. 400-414.Research output: Contribution to journal › Article
}
TY - JOUR
T1 - Research Review
T2 - Functional brain connectivity and child psychopathology - Overview and methodological considerations for investigators new to the field
AU - Matthews, Marguerite
AU - Fair, Damien
PY - 2015/4/1
Y1 - 2015/4/1
N2 - Background Functional connectivity MRI is an emerging technique that can be used to investigate typical and atypical brain function in developing and aging populations. Despite some of the current confounds in the field of functional connectivity MRI, the translational potential of the technique available to investigators may eventually be used to improve diagnosis, early disease detection, and therapy monitoring. Method and Scope Based on a comprehensive survey of the literature, this review offers an introduction of resting-state functional connectivity for new investigators to the field of resting-state functional connectivity. We discuss a brief history of the technique, various methods of analysis, the relationship of functional networks to behavior, as well as the translational potential of functional connectivity MRI to investigate neuropsychiatric disorders. We also address some considerations and limitations with data analysis and interpretation. Conclusions The information provided in this review should serve as a foundation for investigators new to the field of resting-state functional connectivity. The discussion provides a means to better understand functional connectivity and its application to typical and atypical brain function.
AB - Background Functional connectivity MRI is an emerging technique that can be used to investigate typical and atypical brain function in developing and aging populations. Despite some of the current confounds in the field of functional connectivity MRI, the translational potential of the technique available to investigators may eventually be used to improve diagnosis, early disease detection, and therapy monitoring. Method and Scope Based on a comprehensive survey of the literature, this review offers an introduction of resting-state functional connectivity for new investigators to the field of resting-state functional connectivity. We discuss a brief history of the technique, various methods of analysis, the relationship of functional networks to behavior, as well as the translational potential of functional connectivity MRI to investigate neuropsychiatric disorders. We also address some considerations and limitations with data analysis and interpretation. Conclusions The information provided in this review should serve as a foundation for investigators new to the field of resting-state functional connectivity. The discussion provides a means to better understand functional connectivity and its application to typical and atypical brain function.
KW - child psychopathology
KW - fMRI
KW - functional connectivity
KW - machine learning
KW - neuropsychiatric disorders
KW - resting-state networks
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UR - http://www.scopus.com/inward/citedby.url?scp=84924801615&partnerID=8YFLogxK
U2 - 10.1111/jcpp.12335
DO - 10.1111/jcpp.12335
M3 - Article
C2 - 25307115
AN - SCOPUS:84924801615
VL - 56
SP - 400
EP - 414
JO - Journal of Child Psychology and Psychiatry and Allied Disciplines
JF - Journal of Child Psychology and Psychiatry and Allied Disciplines
SN - 0021-9630
IS - 4
ER -