Research Opportunities in Autonomic Neural Mechanisms of Cardiopulmonary Regulation: A Report From the National Heart, Lung, and Blood Institute and the National Institutes of Health Office of the Director Workshop

Reena Mehra, Olga A. Tjurmina, Olujimi A. Ajijola, Rishi Arora, Donald C. Bolser, Mark W. Chapleau, Peng Sheng Chen, Colleen E. Clancy, Brian P. Delisle, Michael R. Gold, Jeffrey J. Goldberger, David S. Goldstein, Beth A. Habecker, M. Louis Handoko, Robert Harvey, James P. Hummel, Thomas Hund, Christian Meyer, Susan Redline, Crystal M. RipplingerMarc A. Simon, Virend K. Somers, Stavros Stavrakis, Thomas Taylor-Clark, Bradley Joel Undem, Richard L. Verrier, Irving H. Zucker, George Sopko, Kalyanam Shivkumar

Research output: Contribution to journalReview articlepeer-review

Abstract

This virtual workshop was convened by the National Heart, Lung, and Blood Institute, in partnership with the Office of Strategic Coordination of the Office of the National Institutes of Health Director, and held September 2 to 3, 2020. The intent was to assemble a multidisciplinary group of experts in basic, translational, and clinical research in neuroscience and cardiopulmonary disorders to identify knowledge gaps, guide future research efforts, and foster multidisciplinary collaborations pertaining to autonomic neural mechanisms of cardiopulmonary regulation. The group critically evaluated the current state of knowledge of the roles that the autonomic nervous system plays in regulation of cardiopulmonary function in health and in pathophysiology of arrhythmias, heart failure, sleep and circadian dysfunction, and breathing disorders. Opportunities to leverage the Common Fund's SPARC (Stimulating Peripheral Activity to Relieve Conditions) program were characterized as related to nonpharmacologic neuromodulation and device-based therapies. Common themes discussed include knowledge gaps, research priorities, and approaches to develop novel predictive markers of autonomic dysfunction. Approaches to precisely target neural pathophysiological mechanisms to herald new therapies for arrhythmias, heart failure, sleep and circadian rhythm physiology, and breathing disorders were also detailed.

Original languageEnglish (US)
Pages (from-to)265-293
Number of pages29
JournalJACC: Basic to Translational Science
Volume7
Issue number3
DOIs
StatePublished - Mar 2022
Externally publishedYes

Keywords

  • asthma
  • atrial fibrillation
  • autonomic nervous system
  • cardiopulmonary
  • chronic obstructive pulmonary disease
  • circadian
  • heart failure
  • pulmonary arterial hypertension
  • sleep apnea
  • ventricular arrhythmia

ASJC Scopus subject areas

  • Cardiology and Cardiovascular Medicine

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