Rescue Therapy for Refractory Vasospasm after Subarachnoid Hemorrhage

Julia C. Durrant, Holly E. Hinson

Research output: Contribution to journalReview article

9 Scopus citations

Abstract

Vasospasm and delayed cerebral ischemia remain to be the common causes of increased morbidity and mortality after aneurysmal subarachnoid hemorrhage. The majority of clinical vasospasm responds to hemodynamic augmentation and direct vascular intervention; however, a percentage of patients continue to have symptoms and neurological decline. Despite suboptimal evidence, clinicians have several options in treating refractory vasospasm in aneurysmal subarachnoid hemorrhage (aSAH), including cerebral blood flow enhancement, intra-arterial manipulations, and intra-arterial and intrathecal infusions. This review addresses standard treatments as well as emerging novel therapies aimed at improving cerebral perfusion and ameliorating the neurologic deterioration associated with vasospasm and delayed cerebral ischemia.

Original languageEnglish (US)
Pages (from-to)1-8
Number of pages8
JournalCurrent neurology and neuroscience reports
Volume15
Issue number2
DOIs
StatePublished - Jan 1 2015

Keywords

  • Aneurysmal subarachnoid hemorrhage
  • Delayed cerebral ischemia
  • Hemodynamic augmentation
  • Intraluminal balloon angioplasty
  • Refractory vasospasm
  • Vasospasm

ASJC Scopus subject areas

  • Neuroscience(all)
  • Clinical Neurology

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