Reproducibility of regional brain metabolic responses to lorazepam

Gene Jack Wang, Nora D. Volkow, John Overall, Robert Hitzemann, Naomi Pappas, Kathy Pascani, Joanna S. Fowler

Research output: Contribution to journalArticle

40 Citations (Scopus)

Abstract

Changes in regional brain glucose metabolism in response to benzodiazepine agonists have been used as indicators of benzodiazepine-GABA receptor function. The purpose of this study was to assess the reproducibility of these responses. Methods: Sixteen healthy right-handed men underwent scanning with PET and [18F]fluorodeoxyglucose (FDG) twice: before placebo and before lorazepam (30 μg/kg). The same double FDG procedure was repeated 6-8 wk later on the men to assess test-retest reproducibility. Results: The regional absolute brain metabolic values obtained during the second evaluation were significantly lower than those obtained from the first evaluation regardless of condition (p ≤ 0.001). Lorazepam significantly and consistently decreased both whole-brain metabolism and the magnitude. The regional pattern of the changes were comparable for both studies (12.3% ± 6.9% and 13.7% ± 7.4%). Lorazepam effects were the largest in the thalamus (22.2% ± 8.6% and 22.4% ± 6.9%) and occipital cortex (19% ± 8.9% and 21.8% ± 8.9%). Relative metabolic measures were highly reproducible both for pharmacologic and replication condition. Conclusion: This study measured the test-retest reproducibility in regional brain metabolic responses, and although the global and regional metabolic values were significantly lower for the repeated evaluation, the response to lorazepam was highly reproducible.

Original languageEnglish (US)
Pages (from-to)1609-1613
Number of pages5
JournalJournal of Nuclear Medicine
Volume37
Issue number10
StatePublished - Oct 1996
Externally publishedYes

Fingerprint

Lorazepam
Brain
Occipital Lobe
Fluorodeoxyglucose F18
GABA-A Receptors
Thalamus
Benzodiazepines
Placebos
Glucose

Keywords

  • cerebral glucose metabolism
  • lorazepam
  • pharmacological challenge

ASJC Scopus subject areas

  • Radiological and Ultrasound Technology

Cite this

Wang, G. J., Volkow, N. D., Overall, J., Hitzemann, R., Pappas, N., Pascani, K., & Fowler, J. S. (1996). Reproducibility of regional brain metabolic responses to lorazepam. Journal of Nuclear Medicine, 37(10), 1609-1613.

Reproducibility of regional brain metabolic responses to lorazepam. / Wang, Gene Jack; Volkow, Nora D.; Overall, John; Hitzemann, Robert; Pappas, Naomi; Pascani, Kathy; Fowler, Joanna S.

In: Journal of Nuclear Medicine, Vol. 37, No. 10, 10.1996, p. 1609-1613.

Research output: Contribution to journalArticle

Wang, GJ, Volkow, ND, Overall, J, Hitzemann, R, Pappas, N, Pascani, K & Fowler, JS 1996, 'Reproducibility of regional brain metabolic responses to lorazepam', Journal of Nuclear Medicine, vol. 37, no. 10, pp. 1609-1613.
Wang GJ, Volkow ND, Overall J, Hitzemann R, Pappas N, Pascani K et al. Reproducibility of regional brain metabolic responses to lorazepam. Journal of Nuclear Medicine. 1996 Oct;37(10):1609-1613.
Wang, Gene Jack ; Volkow, Nora D. ; Overall, John ; Hitzemann, Robert ; Pappas, Naomi ; Pascani, Kathy ; Fowler, Joanna S. / Reproducibility of regional brain metabolic responses to lorazepam. In: Journal of Nuclear Medicine. 1996 ; Vol. 37, No. 10. pp. 1609-1613.
@article{9d8036381a4547ecb5b7843c8eadd555,
title = "Reproducibility of regional brain metabolic responses to lorazepam",
abstract = "Changes in regional brain glucose metabolism in response to benzodiazepine agonists have been used as indicators of benzodiazepine-GABA receptor function. The purpose of this study was to assess the reproducibility of these responses. Methods: Sixteen healthy right-handed men underwent scanning with PET and [18F]fluorodeoxyglucose (FDG) twice: before placebo and before lorazepam (30 μg/kg). The same double FDG procedure was repeated 6-8 wk later on the men to assess test-retest reproducibility. Results: The regional absolute brain metabolic values obtained during the second evaluation were significantly lower than those obtained from the first evaluation regardless of condition (p ≤ 0.001). Lorazepam significantly and consistently decreased both whole-brain metabolism and the magnitude. The regional pattern of the changes were comparable for both studies (12.3{\%} ± 6.9{\%} and 13.7{\%} ± 7.4{\%}). Lorazepam effects were the largest in the thalamus (22.2{\%} ± 8.6{\%} and 22.4{\%} ± 6.9{\%}) and occipital cortex (19{\%} ± 8.9{\%} and 21.8{\%} ± 8.9{\%}). Relative metabolic measures were highly reproducible both for pharmacologic and replication condition. Conclusion: This study measured the test-retest reproducibility in regional brain metabolic responses, and although the global and regional metabolic values were significantly lower for the repeated evaluation, the response to lorazepam was highly reproducible.",
keywords = "cerebral glucose metabolism, lorazepam, pharmacological challenge",
author = "Wang, {Gene Jack} and Volkow, {Nora D.} and John Overall and Robert Hitzemann and Naomi Pappas and Kathy Pascani and Fowler, {Joanna S.}",
year = "1996",
month = "10",
language = "English (US)",
volume = "37",
pages = "1609--1613",
journal = "Journal of Nuclear Medicine",
issn = "0161-5505",
publisher = "Society of Nuclear Medicine Inc.",
number = "10",

}

TY - JOUR

T1 - Reproducibility of regional brain metabolic responses to lorazepam

AU - Wang, Gene Jack

AU - Volkow, Nora D.

AU - Overall, John

AU - Hitzemann, Robert

AU - Pappas, Naomi

AU - Pascani, Kathy

AU - Fowler, Joanna S.

PY - 1996/10

Y1 - 1996/10

N2 - Changes in regional brain glucose metabolism in response to benzodiazepine agonists have been used as indicators of benzodiazepine-GABA receptor function. The purpose of this study was to assess the reproducibility of these responses. Methods: Sixteen healthy right-handed men underwent scanning with PET and [18F]fluorodeoxyglucose (FDG) twice: before placebo and before lorazepam (30 μg/kg). The same double FDG procedure was repeated 6-8 wk later on the men to assess test-retest reproducibility. Results: The regional absolute brain metabolic values obtained during the second evaluation were significantly lower than those obtained from the first evaluation regardless of condition (p ≤ 0.001). Lorazepam significantly and consistently decreased both whole-brain metabolism and the magnitude. The regional pattern of the changes were comparable for both studies (12.3% ± 6.9% and 13.7% ± 7.4%). Lorazepam effects were the largest in the thalamus (22.2% ± 8.6% and 22.4% ± 6.9%) and occipital cortex (19% ± 8.9% and 21.8% ± 8.9%). Relative metabolic measures were highly reproducible both for pharmacologic and replication condition. Conclusion: This study measured the test-retest reproducibility in regional brain metabolic responses, and although the global and regional metabolic values were significantly lower for the repeated evaluation, the response to lorazepam was highly reproducible.

AB - Changes in regional brain glucose metabolism in response to benzodiazepine agonists have been used as indicators of benzodiazepine-GABA receptor function. The purpose of this study was to assess the reproducibility of these responses. Methods: Sixteen healthy right-handed men underwent scanning with PET and [18F]fluorodeoxyglucose (FDG) twice: before placebo and before lorazepam (30 μg/kg). The same double FDG procedure was repeated 6-8 wk later on the men to assess test-retest reproducibility. Results: The regional absolute brain metabolic values obtained during the second evaluation were significantly lower than those obtained from the first evaluation regardless of condition (p ≤ 0.001). Lorazepam significantly and consistently decreased both whole-brain metabolism and the magnitude. The regional pattern of the changes were comparable for both studies (12.3% ± 6.9% and 13.7% ± 7.4%). Lorazepam effects were the largest in the thalamus (22.2% ± 8.6% and 22.4% ± 6.9%) and occipital cortex (19% ± 8.9% and 21.8% ± 8.9%). Relative metabolic measures were highly reproducible both for pharmacologic and replication condition. Conclusion: This study measured the test-retest reproducibility in regional brain metabolic responses, and although the global and regional metabolic values were significantly lower for the repeated evaluation, the response to lorazepam was highly reproducible.

KW - cerebral glucose metabolism

KW - lorazepam

KW - pharmacological challenge

UR - http://www.scopus.com/inward/record.url?scp=0029839940&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=0029839940&partnerID=8YFLogxK

M3 - Article

VL - 37

SP - 1609

EP - 1613

JO - Journal of Nuclear Medicine

JF - Journal of Nuclear Medicine

SN - 0161-5505

IS - 10

ER -