Reproducibility of anterior chamber angle measurements obtained with anterior segment optical coherence tomography

Sunita Radhakrishnan, Jovina See, Scott D. Smith, Winifred P. Nolan, Zheng Ce, David S. Friedman, David Huang, Yan Li, Tin Aung, Paul T K Chew

Research output: Contribution to journalArticle

107 Citations (Scopus)

Abstract

PURPOSE. To evaluate the reproducibility of anterior chamber (AC) angle measurements obtained using anterior segment optical coherence tomography (AS-OCT). METHODS. Patients with suspected glaucoma and those with glaucoma, ocular hypertension, or anatomically narrow angles were recruited from the glaucoma service at the National University Hospital, Singapore. All subjects underwent imaging of the nasal, temporal, and inferior AC angles with an AS-OCT prototype under standardized dark and light conditions. For short-term reproducibility analysis, a single observer acquired two sets of images followed by a third set of images acquired by a second observer. The interval between sessions was 10 minutes. For long-term reproducibility analysis, a single observer acquired two sets of images at least 24 hours apart. Images were measured using custom software to determine the AC depth (ACD), angle opening distance at 500 μm (AOD500), angle recess area at 500 μm (ARA500), and trabecular-iris space area at 500 μm (TISA 500). The intraclass correlation coefficient (ICC) was calculated as a measure of intraobserver and interobserver reproducibility. RESULTS. Twenty eyes of 20 patients were analyzed for short-term reproducibility, and 23 eyes of 23 patients were analyzed for long-term reproducibility. AC depth measurement demonstrated excellent reproducibility (ICC 0.93-1.00) in both dark and light conditions. For the nasal and temporal quadrants, all AC angle parameters demonstrated good to excellent short-term (ICC 0.67-0.90) and long-term (ICC 0.56-0.93) reproducibility in both dark and light conditions. In the inferior quadrant, reproducibility was lower in all categories of analysis and varied from poor to good (ICC 0.31-0.73). CONCLUSIONS. AS-OCT allows quantitative assessment of the AC angle. The reproducibility of AC angle measurements was good to excellent for the nasal and temporal quadrants. The lower reproducibility of measurements in the inferior quadrant may be unique to this prototype due to difficulty in acquiring high-quality images of the inferior angle. Further assessment of the commercially available AS-OCT is needed to clarify this finding.

Original languageEnglish (US)
Pages (from-to)3683-3688
Number of pages6
JournalInvestigative Ophthalmology and Visual Science
Volume48
Issue number8
DOIs
StatePublished - Aug 2007
Externally publishedYes

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Optical Coherence Tomography
Anterior Chamber
Nose
Glaucoma
Light
Ocular Hypertension
Singapore
Iris
Software

ASJC Scopus subject areas

  • Ophthalmology

Cite this

Reproducibility of anterior chamber angle measurements obtained with anterior segment optical coherence tomography. / Radhakrishnan, Sunita; See, Jovina; Smith, Scott D.; Nolan, Winifred P.; Ce, Zheng; Friedman, David S.; Huang, David; Li, Yan; Aung, Tin; Chew, Paul T K.

In: Investigative Ophthalmology and Visual Science, Vol. 48, No. 8, 08.2007, p. 3683-3688.

Research output: Contribution to journalArticle

Radhakrishnan, Sunita ; See, Jovina ; Smith, Scott D. ; Nolan, Winifred P. ; Ce, Zheng ; Friedman, David S. ; Huang, David ; Li, Yan ; Aung, Tin ; Chew, Paul T K. / Reproducibility of anterior chamber angle measurements obtained with anterior segment optical coherence tomography. In: Investigative Ophthalmology and Visual Science. 2007 ; Vol. 48, No. 8. pp. 3683-3688.
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abstract = "PURPOSE. To evaluate the reproducibility of anterior chamber (AC) angle measurements obtained using anterior segment optical coherence tomography (AS-OCT). METHODS. Patients with suspected glaucoma and those with glaucoma, ocular hypertension, or anatomically narrow angles were recruited from the glaucoma service at the National University Hospital, Singapore. All subjects underwent imaging of the nasal, temporal, and inferior AC angles with an AS-OCT prototype under standardized dark and light conditions. For short-term reproducibility analysis, a single observer acquired two sets of images followed by a third set of images acquired by a second observer. The interval between sessions was 10 minutes. For long-term reproducibility analysis, a single observer acquired two sets of images at least 24 hours apart. Images were measured using custom software to determine the AC depth (ACD), angle opening distance at 500 μm (AOD500), angle recess area at 500 μm (ARA500), and trabecular-iris space area at 500 μm (TISA 500). The intraclass correlation coefficient (ICC) was calculated as a measure of intraobserver and interobserver reproducibility. RESULTS. Twenty eyes of 20 patients were analyzed for short-term reproducibility, and 23 eyes of 23 patients were analyzed for long-term reproducibility. AC depth measurement demonstrated excellent reproducibility (ICC 0.93-1.00) in both dark and light conditions. For the nasal and temporal quadrants, all AC angle parameters demonstrated good to excellent short-term (ICC 0.67-0.90) and long-term (ICC 0.56-0.93) reproducibility in both dark and light conditions. In the inferior quadrant, reproducibility was lower in all categories of analysis and varied from poor to good (ICC 0.31-0.73). CONCLUSIONS. AS-OCT allows quantitative assessment of the AC angle. The reproducibility of AC angle measurements was good to excellent for the nasal and temporal quadrants. The lower reproducibility of measurements in the inferior quadrant may be unique to this prototype due to difficulty in acquiring high-quality images of the inferior angle. Further assessment of the commercially available AS-OCT is needed to clarify this finding.",
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T1 - Reproducibility of anterior chamber angle measurements obtained with anterior segment optical coherence tomography

AU - Radhakrishnan, Sunita

AU - See, Jovina

AU - Smith, Scott D.

AU - Nolan, Winifred P.

AU - Ce, Zheng

AU - Friedman, David S.

AU - Huang, David

AU - Li, Yan

AU - Aung, Tin

AU - Chew, Paul T K

PY - 2007/8

Y1 - 2007/8

N2 - PURPOSE. To evaluate the reproducibility of anterior chamber (AC) angle measurements obtained using anterior segment optical coherence tomography (AS-OCT). METHODS. Patients with suspected glaucoma and those with glaucoma, ocular hypertension, or anatomically narrow angles were recruited from the glaucoma service at the National University Hospital, Singapore. All subjects underwent imaging of the nasal, temporal, and inferior AC angles with an AS-OCT prototype under standardized dark and light conditions. For short-term reproducibility analysis, a single observer acquired two sets of images followed by a third set of images acquired by a second observer. The interval between sessions was 10 minutes. For long-term reproducibility analysis, a single observer acquired two sets of images at least 24 hours apart. Images were measured using custom software to determine the AC depth (ACD), angle opening distance at 500 μm (AOD500), angle recess area at 500 μm (ARA500), and trabecular-iris space area at 500 μm (TISA 500). The intraclass correlation coefficient (ICC) was calculated as a measure of intraobserver and interobserver reproducibility. RESULTS. Twenty eyes of 20 patients were analyzed for short-term reproducibility, and 23 eyes of 23 patients were analyzed for long-term reproducibility. AC depth measurement demonstrated excellent reproducibility (ICC 0.93-1.00) in both dark and light conditions. For the nasal and temporal quadrants, all AC angle parameters demonstrated good to excellent short-term (ICC 0.67-0.90) and long-term (ICC 0.56-0.93) reproducibility in both dark and light conditions. In the inferior quadrant, reproducibility was lower in all categories of analysis and varied from poor to good (ICC 0.31-0.73). CONCLUSIONS. AS-OCT allows quantitative assessment of the AC angle. The reproducibility of AC angle measurements was good to excellent for the nasal and temporal quadrants. The lower reproducibility of measurements in the inferior quadrant may be unique to this prototype due to difficulty in acquiring high-quality images of the inferior angle. Further assessment of the commercially available AS-OCT is needed to clarify this finding.

AB - PURPOSE. To evaluate the reproducibility of anterior chamber (AC) angle measurements obtained using anterior segment optical coherence tomography (AS-OCT). METHODS. Patients with suspected glaucoma and those with glaucoma, ocular hypertension, or anatomically narrow angles were recruited from the glaucoma service at the National University Hospital, Singapore. All subjects underwent imaging of the nasal, temporal, and inferior AC angles with an AS-OCT prototype under standardized dark and light conditions. For short-term reproducibility analysis, a single observer acquired two sets of images followed by a third set of images acquired by a second observer. The interval between sessions was 10 minutes. For long-term reproducibility analysis, a single observer acquired two sets of images at least 24 hours apart. Images were measured using custom software to determine the AC depth (ACD), angle opening distance at 500 μm (AOD500), angle recess area at 500 μm (ARA500), and trabecular-iris space area at 500 μm (TISA 500). The intraclass correlation coefficient (ICC) was calculated as a measure of intraobserver and interobserver reproducibility. RESULTS. Twenty eyes of 20 patients were analyzed for short-term reproducibility, and 23 eyes of 23 patients were analyzed for long-term reproducibility. AC depth measurement demonstrated excellent reproducibility (ICC 0.93-1.00) in both dark and light conditions. For the nasal and temporal quadrants, all AC angle parameters demonstrated good to excellent short-term (ICC 0.67-0.90) and long-term (ICC 0.56-0.93) reproducibility in both dark and light conditions. In the inferior quadrant, reproducibility was lower in all categories of analysis and varied from poor to good (ICC 0.31-0.73). CONCLUSIONS. AS-OCT allows quantitative assessment of the AC angle. The reproducibility of AC angle measurements was good to excellent for the nasal and temporal quadrants. The lower reproducibility of measurements in the inferior quadrant may be unique to this prototype due to difficulty in acquiring high-quality images of the inferior angle. Further assessment of the commercially available AS-OCT is needed to clarify this finding.

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